The cause of many forms of vasculitis is not understood. For many forms of vasculitis there is a presence of autoantibodies that are sometimes used in classification, as in ANCA- associated vasculitides (Anti-neutrophil cytoplasmic antibodies).
ANCAs (anti-neutrophil cytoplasmic antibodies) are a family of auto-antibodies related to vasculitis and inflammatory disorders. These antibodies are considered to be major diagnostic tools for the diagnosis and follow up of systemic vasculitis.
A prompt diagnosis is essential for patients with medical conditions such as goodpasture’s Syndrome, granulomatosis with polyangiitis (Wegener’s granulomatosis) or microscopic polyangiitis.
At some time during the course of illness, as many as one third of patients with for example Goodpasture syndrome have circulating antineutrophilic cytoplasmic antibodies (ANCAs) in addition to anti-GBM antibody. In most cases, the ANCA antibodies precede the development of anti-GBM antibodies by months to years.
Fast and simultaneous detection of autoantibodies against GBM, Proteinase 3 (PR3-ANCA) and Myeloperoxidase (MPO-ANCA) is possible with the Wieslab® ANCA/GBM portfolio.