At times when the sample is not directly sent, the sample should be stored in a refrigerator (about 2-8 °C for up to one week) or freezer (about -20 °C for prolonged storage) awaiting transport.
Blood should be collected in plain tubes (serum tubes) without coagulants or other additives.
Both venous and capillary samples are acceptable.
3 mL serum (7 mL blood) will be enough for approximately 15 tests.
Usually one tube is enough.
The sample should be coagulating at least 30 minutes and then centrifuged at ambient temperature
Separate serum into plain tube/s
Serum should be kept cold until transport
Transport at room temperature, standard postal letter is acceptable (padded envelope marked UN 3373)
CSF (Cerebrospinal fluid)
3 mL CSF will be enough for approximately 10 tests. It is not necessary to freeze these samples before transport. The samples can be sent in padded envelopes in room temperature.
The serum samples and EDTA-plasma should be frozen and shipped on dry ice.
Serum (C3, C4, C1q and functional complement assay)
Serum samples for complement analysis (C3, C4, C1q, and functional complement assay) should be collected in plain tubes (serum tubes) without coagulants or other additives.
Turn the test tube at least 5 times after sampling
The sample should be coagulating for at least 30 minutes and then centrifuged 10 minutes
Separate serum into two plain tubes and transport it on dry ice
The sample should be centrifuged for 10 minutes at ambient temperature
Separate plasma into a plain tube and transport it on dry ice – within 24 hours of sampling
Biomarkers (in CSF)
Always use polypropylene tubes for collecting, centrifuging and transportation.
Adults: Collect the first 10-12 mL CSF
Children (<16 years): Collect the first 3 mL CSF
In case of heavy bleeding, discard the first mL CSF, and note this on the request form
Samples should be centrifuged at 1300-1800g for 10 min
The supernatant should be transferred to a new polypropylene tube before aliquoting as described below:
Alzheimer markers and markers of neuronal damage (Parenchymal): At least 0.5 mL CSF divided in 3 polypropylene cryotubes and frozen.
Neuromyelitis Optica Spectrum Disease: At least 0.5 mL CSF divided in 2 polypropylene cryotubes and frozen.
The samples must be packed with dry ice when shipped.
NOTE! Samples must not be thawed after freezing and never send frozen samples on Fridays.
For this assay, the following samples are needed:
Serum: 3 mL (Trib2)
CSF: 0,5 mL (Orexin/Hypokretin) and
EDTA-plasma: 2,5 mL (HLA-DQB*06:02)*
The sample should be stored in a refrigerator (about 2-8 °C for up to one week) awaiting transport. Transport at room temperature, standard postal letter is acceptable (padded envelope marked UN 3373).
The sample is preferably collected the same day as the next planned drug injection/infusion but before drug administration.
Cmin is the minimal drug concentration at steady state and when the variations of drug levels in serum are the lowest.
The levels of neutralizing anti-drug antibodies are not accurately determined with these methods if sera contain detectable levels of drug.
Take a venous or capillary blood sample in a tube without additive, let the sample clot for approximately 30 minutes and centrifuge it.
Send serum by ordinary mail or on dry ice, please see the instructions after each sample number below for the correct transport condition. Cold packs are recommended for international transport of specimen that can be sent in “room temperature”.
If the sample cannot be sent immediately it should be stored cold (2-8° C) in a refrigerator for up to one week or freezer (-20° C) until shipment.
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