PM/Scl (100kD) antibodies

IndicationSuspicion of polymyositis/scleroderma overlap syndrome, scleroderma, unclear myositis.MethodFluorescence enzyme immunoassay (FEIA).AnswerThe result is given as negative, borderline or positive.InterpretationThe PM/Scl antigen is found in the exosome, a complex consisting of 11-16 proteins in the granular part of the nucleoli and in the nucleoplasma. The proteins act as exoribonucleases during the RNA processing.

Antibodies against the PM-Scl complex are associated with polymyositic/systemic sclerosis overlap syndrome. The antibodies are usually associated with positive ANA with nucleolar patterns. Anti-PM-Scl may be directed to different subunits in the PM-Scl complex, usually the 75 kD and 100 kD subunits. Anti-PM-Scl is often associated with Raynaud's phenomenon, arthritis, muscle aches and effects on the skin and lungs.

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PM/Scl (100kD)-antikroppar

IndikationMisstanke om polymyosit/sklerodermi overlap syndrom, sklerodermi, oklar myosit.MetodFluorescensimmunanalys (FEIA)SvarResultatet anges som negativt, gränsvärde eller positivt.TolkningPM/Scl antigenet finns i exosomen, ett komplex bestående av 11-16 proteiner som finns i den granulära delen av nukleoli och i nukleoplasman. Proteinerna fungerar som exoribonukleas under RNA processningen.

Antikroppar mot PM-Scl-komplexet är associerade med polymyosit/systemisk skleros överlappningssyndrom. Antikropparna är vanligtvis associerade med positiv ANA med nukleolärt mönster. Anti-PM-Scl kan vara riktade mot olika subenheter i PM-Scl-komplexet, vanligen subenheterna 75 kD och 100 kD. Anti-PM-Scl är ofta associerade med Raynaud-fenomen, artrit, muskelpåverkan och påverkan på hud och lungor.

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