This study employed custom-developed iLite® IL-23 and IFN-ɣ to set up a high-throughput cell-based screening strategy to identify small-molecule inhibitors of IL-23 signaling.
The findings showed that assay performance was robust and allowed for identifying 24 selective IL-23 inhibitors; these findings are encouraging and could serve as a foundation for developing small-molecule inhibitors of the IL-23 pathway in the future.