The complement system is an integral part of the innate immune response. Given its important role in many human disorders, complement activation measurements are important in a wide range of applications.
The individual complement profile of a patient gives valuable information of the course and severity of a disease, and as a consequence, complement assays have evolved as essential tools not only in initial diagnosis but for following disease progression and monitoring complement-targeted therapies.
To determine whether deficiencies, overactivation and/or dysregulation in the complement system are causing, or contributing to, a person's disease or condition activity biomarkers can be used, and these types of tools have become increasingly available in routine clinical use.