DIAGNOSTIC TEST PANEL 533

Autoimmune Nodopathy/CIDP – Extended Analysis with Reflex (IgG1-4)

Diagnostic test panel for antibodies against NF155, NF186, CNTN1, and CASPR1. For suspicion of inflammatory Neuropathy/Autoimmune Nodopathy.

urgent

Available as urgent test with results within 48 h.

Indication

Suspicion of inflammatory Neuropathy/Autoimmune Nodopathy

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

Within Sweden

  • room temperature

International

  • cold

Clinical background

Autoimmune nodopathies have until recently been regarded as subgroups of CIDP but are distinct in both disease course and treatment and are now regarded as separate disorders.

The panel includes analysis of the following auto-antibodies that may be helpful in the investigation of patients with CIDP-like symptoms. Initial screening for IgG is performed with Indirect immunofluorescence (IIF) using transfected cells. If the sample is positive, further analysis of subclasses IgG1, IgG2, IgG3, and IgG4 is performed with a live cell-based assay (CBA).

IgG1 and/or IgG3 subclass antibodies are complement activating, which is associated with a more aggressive disease course.

  • Neurofascin-155 and Neurofascin-186 antibodies (IgG). Neurofascin-155 (NF155) is a paranodal protein while Neurofascin-186 (NF186) is a protein present in the nodes of Ranvier. IgG antibodies against NF155 and NF186 have been reported in autoimmune nodopathy. Simultaneous presence of antibodies against NF155 and NF186 is seen in pan-neurofascin nodopathy.
  • Contactin-1 antibodies (IgG). Contactin-1 (CNTN1) is a paranodal protein. IgG antibodies against CNTN1 have been reported in autoimmune nodopathy.
  • CASPR1 antibodies (IgG). Contactin-associated protein 1 (CASPR1) is a paranodal protein. IgG antibodies against CASPR1 have been reported in autoimmune nodopathy.

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How to order

This test panel is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-08-18