T-Cell Activation Bioassays

SVAR Life Science's iLite^® T-Cell Activation Bioassays are cell-based reporter gene assays designed to measure T-cell activation through biologically relevant signaling pathways. They provide a functional readout of immune cell activation in vitro.

Many immunotherapies, including bispecific antibodies and T-cell-engaging therapeutics, rely on activating T cells to generate an anti-tumor immune response. Measuring T-cell activation helps evaluate biological activity and therapeutic performance.

iLite^® T-Cell Activation Bioassays use engineered reporter cells with a luciferase-based readout, providing a convenient and reproducible way to measure functional T-cell responses. The platform also incorporates an internal control reporter to support assay consistency.

When the CD3 receptor is activated, intracellular signaling induces reporter gene expression, generating a measurable luminescent signal. This allows quantitative assessment of T-cell activation and biological activity.

Reporter gene assays provide a quantitative, reproducible, and scalable method for measuring T-cell activation, making them well suited for screening, characterization, and potency applications

These assays can support the development of T-cell engagers, bispecific antibodies, immune-modulating biologics, and other therapeutics designed to activate T-cell responses.

Yes. Svar Life Science can develop custom iLite^® reporter gene assays tailored to specific targets, mechanisms of action, and therapeutic programs.