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iLite AAV NAb Assessment

Reliable Detection of Neutralizing Antibodies against AAV Capsids

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Reliable Detection of AAV Neutralizing Antibodies

AAV NAb Bioassays

Detection of neutralizing antibodies (NAbs) in AAV gene therapies is essential. Our AAV NAb cell-based reporter-gene assays, based on our proprietary iLite® technology, offer the tool you need for identifying and assessing Neutralizing Antibodies against AAV capsids.

iLite AAV NAb Reporter Gene Assays

Our AAV NAb assessment bioassays are designed to evaluate the immunogenicity of AAV capsids for different serotypes in gene therapy. They use a two-cell line setup: an AAV-responsive reporter cell and packaging cells for the vector serotype.

  • Customization for any capsid – both traditional and recombinant
  • Packaging cells eliminate the need for vector production
  • Reduced incubation time for fast and high-quality results
  • "Assay-ready" format for rapid and convenient use
  • A secondary reporter gene that acts as an internal control, compensating for differences in cell number and matrix effects

Our AAV NAb Reporter-Gene Assays

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BM6100

iLite® AAV Responsive Reporter Assay Ready Cells

Reporter cell line designed to quantify AAV vector transduction efficiency and detect NAbs that impair gene delivery

CELL-BASED
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Cell-based reporter gene bioassay | Gene Therapy Bioassays | BM6100 | AAV | Cell-based reporter gene assay | Luminescence |
BM6002

iLite® AAV2 Packaging Assay Ready Cells

Engineered and optimized to produce AAV vectors of serotype 2 for use in NAb detection studies

CELL-BASED
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Cell-based reporter gene bioassay | Gene Therapy Bioassays | BM6002 | AAV | Cell-based reporter gene assay | Luminescence |
BM6005

iLite® AAV5 Packaging Assay Ready Cells

Engineered and optimized to produce AAV vectors of serotype 5 for use in NAb detection studies

CELL-BASED
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Cell-based reporter gene bioassay | Gene Therapy Bioassays | BM6005 | AAV | Cell-based reporter gene assay | Luminescence |
BM6006

iLite® AAV6 Packaging Assay Ready Cells

Engineered and optimized to produce AAV vectors of serotype 6 for use in NAb detection studies

CELL-BASED
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Cell-based reporter gene bioassay | Gene Therapy Bioassays | BM6006 | AAV | Cell-based reporter gene assay | Luminescence |
BM6008

iLite® AAV8 Packaging Assay Ready Cells

Engineered and optimized to produce AAV vectors of serotype 8 for use in NAb detection studies

CELL-BASED
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Cell-based reporter gene bioassay | Gene Therapy Bioassays | BM6008 | AAV | Cell-based reporter gene assay | Luminescence |
BM6009

iLite® AAV9 Packaging Assay Ready Cells

Engineered and optimized to produce AAV vectors of serotype 9 for use in NAb detection studies

CELL-BASED
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Cell-based reporter gene bioassay | Gene Therapy Bioassays | BM6009 | AAV | Cell-based reporter gene assay | Luminescence |

Didn't find what you were looking for?

We offer products customized to your needs. Our custom iLite® reporter-gene assays can be adapted to almost any target. We also offer custom ELISA plates and other products. In addition, you can take advantage of our service offerings and let us do the work for you.

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iLite News

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Transitioning to Second-Generation iLite Cells

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iLite Downloads

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IL-6 Biology, Inhibitors & COVID-19

IL-6 Biology, Inhibitors & COVID-19

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Mechanism-linked Potency Assays Drive Gene Therapy Success

Mechanism-linked Potency Assays Drive Gene Therapy Success

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Developing a Customizable Complement-Dependent Cytotoxicity Assay

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The Immune Response to AAV Gene Therapy

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Development of an FGF21 iLite® Reporter Gene Cell Line

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