DIAGNOSTIC TEST 930
C3d
Diagnostic test for C3d. For investigation of inflammatory system disorders, glomerulonephritis and other conditions in which complement activation is suspected.
Indication
Suspicion of inflammatory disorders with complement activation
Sample material
EDTA-plasma
- Minim. volume: 0,5 mL
Transport
- Within Sweden: frozen
- International: frozen
Method
Nephelometry
Reference interval
<5.3 mg/L
Result
Results are reported as normal or elevated with a concentration (mg/L).
Interpretation
C3 and its fragments (C3b, iC3b, C3d) are key in the complement system, driving inflammation and immune regulation. C3d, a stable end-product of C3 degradation, interacts with CR2 to modulate adaptive immunity.
Elevated levels of C3d indicate complement activation with degradation of C3.
References
- Alkaff FF et al. Clin Kidney J. 2025. Alternative pathway-mediated tubular complement activation in human proteinuric kidney diseases: a proof-of-concept study. PMID: 41215783
- Dragon Durey MA et al. Curr Opin Immunol. 2025. Complement in antiphospholipid syndrome, time to target? PMID: 40774121
- Catanese L et al. Int J Mol Sci. 2024. Non-Invasive Biomarkers for Diagnosis, Risk Prediction, and Therapy Guidance of Glomerular Kidney Diseases: A Comprehensive Review. PMID: 38542491
Included in these panels
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How to order
This test is available worldwide for hospitals, clinics, and physicians.
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Print and complete the request form
Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. -
Prepare your samples
EDTA Plasma: At least 0.5 mL blood plasma (EDTA tubes).
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Send samples and request form
Within Sweden
Send samples frozen to:
Envelopes and smaller boxes:
Wieslab AB, Box 50117, 20211 Malmö, Sweden
Larger boxes and frozen samples:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
International
Send samples frozen to:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
Last updated: 2025-12-05
