DIAGNOSTIC TEST 460, 470
Desmoglein 1 and 3 Antibodies (IgG)
Diagnostic test for antibodies against Desmoglein 1 & 3 (IgG). For suspicion of autoimmune skin disease, e.g., pemphigus, and differential diagnosis of pemphigoid, Epidermolysis Bullosa Aquisita EBA etc.
Indication
Suspicion of pemphigus and differential diagnosis of pemphigoid
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
ELISA
Reference interval
<1.0 negative
Result
Results are reported as negative or positive with a ratio.
Interpretation
Antibodies against Desmoglein is a marker for pemphigus. In pemphigus vulgaris the antibodies are mainly directed against the extracellular domain of Desmoglein 3 but antibodies against Desmoglein 1 may also occur. In pemphigus foliaceus the antibodies are mainly directed against Desmoglein 1.
References
- Hudemann C et al. J Invest Dermatol. 2023. IgG against the Membrane-Proximal Portion of the Desmoglein 3 Ectodomain Induces Loss of Keratinocyte Adhesion, a Hallmark in Pemphigus Vulgaris. PMID: 36089007
- Nili A et al. Expert Rev Clin Immunol. 2021. Current status and prospects for the diagnosis of pemphigus vulgaris. PMID: 34162306
Included in these panels
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How to order
This test is available worldwide for hospitals, clinics, and physicians.
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Print and complete the request form
Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. -
Prepare your samples
Serum: At least 0.5 mL serum (plain serum tubes without additives).
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Send samples and request form
Within Sweden
Samples can be sent at room temperature to:
Envelopes and smaller boxes:
Wieslab AB, Box 50117, 20211 Malmö, Sweden
Larger boxes and frozen samples:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
International
Send samples cold to:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
Last updated: 2025-11-21
