DIAGNOSTIC TEST 460, 470

Desmoglein 1 and 3 Antibodies (IgG)

Diagnostic test for antibodies against Desmoglein 1 & 3 (IgG). For suspicion of autoimmune skin disease, e.g., pemphigus, and differential diagnosis of pemphigoid, Epidermolysis Bullosa Aquisita EBA etc.

Indication

Suspicion of pemphigus and differential diagnosis of pemphigoid

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

ELISA

Reference interval

<1.0 negative

Result

Results are reported as negative or positive with a ratio.

Interpretation

Antibodies against Desmoglein is a marker for pemphigus. In pemphigus vulgaris the antibodies are mainly directed against the extracellular domain of Desmoglein 3 but antibodies against Desmoglein 1 may also occur. In pemphigus foliaceus the antibodies are mainly directed against Desmoglein 1.

References

  • Hudemann C et al. J Invest Dermatol. 2023. IgG against the Membrane-Proximal Portion of the Desmoglein 3 Ectodomain Induces Loss of Keratinocyte Adhesion, a Hallmark in Pemphigus Vulgaris. PMID: 36089007
  • Nili A et al. Expert Rev Clin Immunol. 2021. Current status and prospects for the diagnosis of pemphigus vulgaris. PMID: 34162306

Included in these panels

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How to order

This test is only available as part of a test panel.

Last updated: 2026-09-14