DIAGNOSTIC TEST 959
Ganglionic AChR Antibodies
Diagnostic test for antibodies against Ganglionic AChR2. For suspected autoimmune autonomic neuropathies.
Indication
Suspected autoimmune autonomic neuropathies
Method
The test is performed in serum with Radioimmunoprecipitation (RIA)
Result
The result is reported as negative, borderline or positive with a value.
Reference interval:
<10 pmol/L negative
10-15 pmol/L borderline
Interpretation
Antibodies against nicotinic ganglionic acetylcholine receptors (g-AChR) can cause autoimmune autonomic ganglionopathy (AAG), a rare autoimmune disease affecting the sympathetic and parasympathetic ganglia leading to dysautonomia. The alpha-3 subunit is considered to be the main target antigen. Antibody titers correlates with the severity of symptoms.
References
- Vernino S, Low PA, Fealey RD, Stewart JD, Farrugia G, Lennon VA. Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies. N Engl J Med. 2000 Sep 21;343(12):847-55.PMID: 10995864
- Koike H, Watanabe H, Sobue G. The spectrum of immune-mediated autonomic neuropathies: insights from the clinicopathological features. J Neurol Neurosurg Psychiatry. 2013 Jan;84(1):98-106. PMID: 22906617
Included in these panels
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How to order
This test is available worldwide for hospitals, clinics, and physicians.
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Print and complete the request form
Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. -
Prepare your samples
Serum: At least 0.5 mL serum (plain serum tubes without additives).
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Send samples and request form
Within Sweden
Samples can be sent at room temperature to:
Envelopes and smaller boxes:
Wieslab AB, Box 50117, 20211 Malmö, Sweden
Larger boxes and frozen samples:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
International
Send samples cold to:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
Last updated: 2025-08-18
