DIAGNOSTIC TEST PANEL 506
Inflammatory Neuropathy Screen– Extended Analysis
Diagnostic test panel for antibodies against gangliosides and MAG IgM. For suspicion of inflammatory neuropathy.
Available as urgent test with results within 48 h.
Indication
Suspicion of inflammatory neuropathy
Sample material
Serum
- Minim. volume: 1 mL
Transport
- Within Sweden: room temperature
- International: cold
Clinical background
Inflammatory polyneuropathies can be severe and progress rapidly. Screening for antibodies associated with inflammatory neuropathy should be performed at an early stage of the disease to improve diagnostics and not delay initiation of proper treatment. Serum samples should always be drawn before treatment, which can compromise the serological test results.
Antibodies against gangliosides (GM1-, GT1a-, GQ1b-, GD1a-, GD1b-, GT1b- IgG and IgM) and MAG IgM are associated with motoric and sensomotoric inflammatory neuropathies. Antibodies against multiple gangliosides can often be detected simultaneously due to cross-reactivity as result of their high molecular similarity.
High levels of MAG IgM have been reported in demyelinating neuropathies. In patients with monoclonal IgM gammopathies and neuropathy, antibodies against MAG can be detected in about 50% of the cases.
Autoimmune nodopathies can clinically mimic acute demyelinating polyneuropathy and analysis of antibodies associated with this condition should be performed when suspecting inflammatory neuropathy. This includes IgG antibodies against Neurofascin 155, Neurofascin 186, Contactin1, and CASPR1.
Neurofilament light protein (NfL) is a protein in axonal cytoskeleton and in both the central and peripheral nervous system (CNS and PNS). The concentration of NfL in blood reflects the degree of axonal damage. The half-life of NfL is long and normalization of levels occurs about 6 months after the injury.
Tests included in panel
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How to order
This test panel is available worldwide for hospitals, clinics, and physicians.
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Print and complete the request form
Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. -
Prepare your samples
Serum: At least 1 mL serum (plain serum tubes without additives).
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Send samples and request form
Within Sweden
Samples can be sent at room temperature to:
Envelopes and smaller boxes:
Wieslab AB, Box 50117, 20211 Malmö, Sweden
Larger boxes and frozen samples:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
International
Send samples cold to:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
Last updated: 2026-01-29
