DIAGNOSTIC TEST 989
Orexin (Hypokretin-1)
Diagnostic test for hypocretin/orexin. For suspected narcolepsy.
Indication
Suspicion of narcolepsy
Sample material
CSF
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
RIA
Reference interval
110-200 pg/mL borderline, >200 pg/mL normal
Result
Results are reported as normal, borderline or decreased with concentration.
Interpretation
Hypocretin-1 levels are usually considerably lowered in narcolepsy. The diagnosis is also based on the clinical symptoms and carriage of HLA-DQB1*0602.
References
- Lozano-Tovar S et al. Neurol Sci. 2025. Cerebrospinal-fluid Orexin-A levels in different neurocognitive disorders: a comparison study. PMID: 40198471
- Freeman SA et al. Semin Immunol. 2025. Unraveling the pathophysiology of narcolepsy type 1 through hypothesis-driven and hypothesis-generating approaches. PMID: 40373365
- Vringer M et al. Sleep Med Rev. 2024. Recent insights into the pathophysiology of narcolepsy type 1. PMID: 39241492
Included in these panels
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How to order
This test is available worldwide for hospitals, clinics, and physicians.
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Print and complete the request form
Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. -
Prepare your samples
CSF: At least 0.5 mL CSF (polypropylene tubes).
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Send samples and request form
Within Sweden
Samples can be sent at room temperature to:
Envelopes and smaller boxes:
Wieslab AB, Box 50117, 20211 Malmö, Sweden
Larger boxes and frozen samples:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
International
Send samples cold to:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
Last updated: 2025-12-05
