DIAGNOSTIC TEST 737

SOX1 Antibodies (IgG)

Diagnostic test for antibodies against SOX1. For suspicion of paraneoplastic syndrome.

swedac

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Indication

Suspicion of paraneoplastic syndrome and neuropathy

Sample material

Serum
  • Minim. volume: 0,5 mL

    • CSF

    • Minim. volume: 2,0 mL

    Transport

    Within Sweden

    • room temperature

    International

    • cold

    Method

    Immunoblot

    Reference interval

    Serum

    • <5 negative

    CSF

    • negative

    Result

    Serum

    • results are reported as negative, borderline, or positive with an intensity value.

    CSF

    • results are reported as negative, or positive.

    Interpretation

    Antibodies against SOX1 (anti-glial nuclear antibody, AGNA) are unusual but have been reported to occur in paraneoplastic neuropathy, Lambert-Eaton syndrome, neuropathy and ataxia. SOX1 antibodies are often associated with antibodies against VGCC, Hu, CV2/CRMP5, or amphiphysin. The most common cancer form associated with SOX1 is small-cell lung cancer, but other lung cancer forms have also been reported.

    Antibodies against SOX1 are graded as High-risk antibodies with a frequency of >90% of underlying cancer and a positive result yield 3 points PNS score, according to Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes.

    References

    • Rosenfeld MR, Dalmau J. Neurol Clin. 2018. Paraneoplastic Neurologic Syndromes. PMID: 30072076
    • Balint B et al. Brain. 2018. Movement disorders with neuronal antibodies: syndromic approach, genetic parallels and pathophysiology. PMID: 29053777
    • Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
    • Garza M, Piquet AL. Front Neurol. 2021. Update in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia. PMID: 34489848

    Included in these panels

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    How to order

    This test is available worldwide for hospitals, clinics, and physicians.

    1. Print and complete the request form

      Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

    2. Prepare your samples

      Serum: At least 0.5 mL serum (plain serum tubes without additives).
      CSF: At least 2 mL CSF (polypropylene tubes).

    3. Send samples and request form

      Within Sweden
      Samples can be sent at room temperature to:
      Envelopes and smaller boxes:
      Wieslab AB, Box 50117, 20211 Malmö, Sweden

      Larger boxes and frozen samples:
      Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

      International
      Send samples cold to:
      Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    Read our sampling instructions for more information

    Last updated: 2025-08-18