DIAGNOSTIC TEST 831

VGKC Antibodies (IgG)

Diagnostic test for antibodies against VGKC. For suspicion of autoimmune encephalitis and paraneoplastic symptoms.

Indication

Suspicion of autoimmune encephalitis and paraneoplastic symptoms

Sample material

Serum

  • Minim. volume: 0,5 mL

CSF

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

RIA

Reference interval

Serum: <72 pmol/L negative

CSF: <2 pmol/L negative

Result

Results are reported as negative or positive with a concentration (pmol/L).

Interpretation

Antibodies against potassium channel complex are primarily seen in patients with neuromyotonia, Morvan's syndrome, autoimmune encephalitis, or idiopathic epilepsy. These antibodies are often directed to the potassium channel-associated proteins CASPR2 (contactin-associated protein-2) and LGI1 (leucine-rich, glioma inactivated protein 1), and further analysis of these specificities is recommended.

In serum, the relevance of antibodies with levels below 300 pmol/L is uncertain. In autoimmune encephalitis, the antibody level in serum is often over 300-500 pmol/L.

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).
    CSF: At least 0.5 mL CSF (polypropylene tubes).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-12-05