Vial

INDIVIDUAL TEST 080

Agrin antibodies

Indication

Suspicion of myasthenia gravis. 

Method

Indirect immunofluorescence. The method is not yet validated. 

Response

Reported as negative or positive with titer. Only serum samples are tested. 

Interpretation

Autoantibodies against Agrin have been reported to occur in 2-15% of patients with Myastenia Gravis (MG). However, the diagnostic and prognostic value of anti-Agrin antibodies in MG is unclear.

Referenser

  1. Lazaridis K and Tzartos SJ. Autoantibody Specificities in Myasthenia Gravis; Implications for Improved Diagnostics and TherapeuticsFront Immunol. 2020 Feb 14;11:212.PMID 32117321 
  2. Koneczny I and Herbst R. Myasthenia Gravis: Pathogenic Effects of Autoantibodies on Neuromuscular ArchitectureCells. 2019 Jul 2;8(7)PMID: 31269763 
  3. Michael H. Rivner et. al. MuSK and Myasthenia Gravis due to other Antibodies. Neurol Clin. 2018 May; 36(2): 293–310. 

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Vial

ENSKILD ANALYS 080

Agrin antikroppar

Indikation

Misstanke om myasthenia gravis.

Metod

Indirekt immunofluorescens. Metoden är ännu inte validerad.

Svar

Anges som negativ eller positiv med titer. Endast serum.

Tolkning

Autoantikroppar mot Agrin har rapporterats förekomma hos 2-15% av patienter med Myastenia Gravis (MG). Anti-Agrin-antikropparnas diagnostiska och prognostiska värde vid MG är dock oklar.

Referenser

  1. Lazaridis K and Tzartos SJ. Autoantibody Specificities in Myasthenia Gravis; Implications for Improved Diagnostics and TherapeuticsFront Immunol. 2020 Feb 14;11:212.PMID 32117321 
  2. Koneczny I and Herbst R. Myasthenia Gravis: Pathogenic Effects of Autoantibodies on Neuromuscular ArchitectureCells. 2019 Jul 2;8(7)PMID: 31269763 
  3. Michael H. Rivner et. al. MuSK and Myasthenia Gravis due to other AntibodiesNeurol Clin. 2018 May; 36(2): 293–310. 

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