INDIVIDUAL TEST 080
Agrin Antibodies
Indication
Suspicion of Myasthenia Gravis (MG)
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
Cell-based assay (CBA), indirect immunofluorescence (IIF)
Reference interval
<1:10 negative
Result
Results are reported as negative or positive with titer.
Interpretation
Autoantibodies against Agrin have been reported to occur in 2-15% of patients with Myasthenia Gravis (MG) but the diagnostic and prognostic value is however unclear.
References
- Lazaridis K, Tzartos SJ. Front Immunol. 2020. Autoantibody Specificities in Myasthenia Gravis; Implications for Improved Diagnostics and Therapeutics. PMID 32117321
- Koneczny I, Herbst R. Cells. 2019. Myasthenia Gravis: Pathogenic Effects of Autoantibodies on Neuromuscular Architecture. PMID: 31269763
- Fichtner ML et al. Int Rev Neurobiol. 2025. Autoantibodies in myasthenia gravis. PMID: 40675742
Last updated: 2025-10-09
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ENSKILD ANALYS 080
Agrin-antikroppar
Indikation
Misstanke om myasthenia gravis (MG)
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
Cell-based assay (CBA), indirekt immunofluorescens (IIF)
Referensintervall
<1:10 negativt
Resultat
Resultat anges som negativt eller positivt med titer.
Tolkning
Autoantikroppar mot Agrin har rapporterats förekomma hos 2-15% av patienter med myastenia gravis (MG) men det diagnostiska och prognostiska värdet är dock tveksamt.
Referenser
- Lazaridis K, Tzartos SJ. Front Immunol. 2020. Autoantibody Specificities in Myasthenia Gravis; Implications for Improved Diagnostics and Therapeutics. PMID 32117321
- Koneczny I, Herbst R. Cells. 2019. Myasthenia Gravis: Pathogenic Effects of Autoantibodies on Neuromuscular Architecture. PMID: 31269763
- Fichtner ML et al. Int Rev Neurobiol. 2025. Autoantibodies in myasthenia gravis. PMID: 40675742
Senast uppdaterat: 2025-10-09