INDIVIDUAL TEST 080

Agrin antibodies

IndicationSuspicion of myasthenia gravis. MethodIndirect immunofluorescence. The method is not yet validated. ResponseReported as negative or positive with titer. Only serum samples are tested. InterpretationAutoantibodies against Agrin have been reported to occur in 2-15% of patients with Myastenia Gravis (MG). However, the diagnostic and prognostic value of anti-Agrin antibodies in MG is unclear.

Referenser

  1. Lazaridis K and Tzartos SJ. Autoantibody Specificities in Myasthenia Gravis; Implications for Improved Diagnostics and Therapeutics. Front Immunol. 2020 Feb 14;11:212.PMID 32117321 
  2. Koneczny I and Herbst R. Myasthenia Gravis: Pathogenic Effects of Autoantibodies on Neuromuscular Architecture. Cells. 2019 Jul 2;8(7). PMID: 31269763 
  3. Michael H. Rivner et. al. MuSK and Myasthenia Gravis due to other Antibodies. Neurol Clin. 2018 May; 36(2): 293–310. 

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Autoimmune diagnostics

ENSKILD ANALYS 080

Agrin antikroppar

IndikationMisstanke om myasthenia gravis.

MetodIndirekt immunofluorescens. Metoden är ännu inte validerad.

SvarAnges som negativ eller positiv med titer. Endast serum.

TolkningAutoantikroppar mot Agrin har rapporterats förekomma hos 2-15% av patienter med Myastenia Gravis (MG). Anti-Agrin-antikropparnas diagnostiska och prognostiska värde vid MG är dock oklar.

Referenser

  1. Lazaridis K and Tzartos SJ. Autoantibody Specificities in Myasthenia Gravis; Implications for Improved Diagnostics and Therapeutics. Front Immunol. 2020 Feb 14;11:212.PMID 32117321 
  2. Koneczny I and Herbst R. Myasthenia Gravis: Pathogenic Effects of Autoantibodies on Neuromuscular Architecture. Cells. 2019 Jul 2;8(7). PMID: 31269763 
  3. Michael H. Rivner et. al. MuSK and Myasthenia Gravis due to other Antibodies. Neurol Clin. 2018 May; 36(2): 293–310. 

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