INDIVIDUAL TEST 080
Agrin antibodies
Indication
Suspicion of myasthenia gravis.
Method
Indirect immunofluorescence. The method is not yet validated.
Response
Reported as negative or positive with titer. Only serum samples are tested.
Interpretation
Autoantibodies against Agrin have been reported to occur in 2-15% of patients with Myastenia Gravis (MG). However, the diagnostic and prognostic value of anti-Agrin antibodies in MG is unclear.
Referenser
- Lazaridis K and Tzartos SJ. Autoantibody Specificities in Myasthenia Gravis; Implications for Improved Diagnostics and Therapeutics. Front Immunol. 2020 Feb 14;11:212.PMID 32117321
- Koneczny I and Herbst R. Myasthenia Gravis: Pathogenic Effects of Autoantibodies on Neuromuscular Architecture. Cells. 2019 Jul 2;8(7). PMID: 31269763
- Michael H. Rivner et. al. MuSK and Myasthenia Gravis due to other Antibodies. Neurol Clin. 2018 May; 36(2): 293–310.
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ENSKILD ANALYS 080
Agrin-antikroppar
Indikation
Misstanke om myasthenia gravis.
Metod
Indirekt immunofluorescens. Metoden är ännu inte validerad.
Svar
Anges som negativ eller positiv med titer. Endast serum.
Tolkning
Autoantikroppar mot Agrin har rapporterats förekomma hos 2-15% av patienter med Myastenia Gravis (MG). Anti-Agrin-antikropparnas diagnostiska och prognostiska värde vid MG är dock oklar.
Referenser
- Lazaridis K and Tzartos SJ. Autoantibody Specificities in Myasthenia Gravis; Implications for Improved Diagnostics and Therapeutics. Front Immunol. 2020 Feb 14;11:212.PMID 32117321
- Koneczny I and Herbst R. Myasthenia Gravis: Pathogenic Effects of Autoantibodies on Neuromuscular Architecture. Cells. 2019 Jul 2;8(7). PMID: 31269763
- Michael H. Rivner et. al. MuSK and Myasthenia Gravis due to other Antibodies. Neurol Clin. 2018 May; 36(2): 293–310.