INDIVIDUAL TEST 095
HSP-70 Antibodies
Indication
Suspicion of autoimmune hearing loss
Sample material
Serum
- Minim. volume: 0.5 mL
Transport
Within Sweden
- room temperature
International
- cold
Method
Immunoblot
Reference interval
Negative
Result
Results are reported as negative or positive.
Interpretation
Antibodies against HSP-70 have been reported to occur in up to 40% of patients with idiopathic hearing loss, but the clinical value is unclear.
References
- Yamanobe S, Harris JP. Laryngoscope. 1993. Inner ear-specific autoantibodies. PMID: 7680088
- Shin SO et al. Laryngoscope. 1997. Comparison of anti-heat shock protein 70 (anti-hsp70) and anti-68-kDa inner ear protein in the sera of patients with Meniere's disease. PMID: 9023247
- Moscicki RA et al. JAMA. 1994. Serum antibody to inner ear proteins in patients with progressive hearing loss. Correlation with disease activity and response to corticosteroid treatment. PMID: 8057517
- Hirose K et al. Laryngoscope. 1999. Utility of laboratory testing in autoimmune inner ear disease. PMID: 10569401
Last updated: 2024-08-12
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ENSKILD ANALYS 095
HSP-70-antikroppar
Indikation
Misstanke om autoimmun hörselnedsättning
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
Inom Sverige
- rumstemperatur
Internationellt
- kylt
Metod
Immunoblot
Referensintervall
Negativt
Resultat
Resultat anges som negativt eller positivt.
Tolkning
Antikroppar mot HSP-70 har rapporterats förekomma hos upp till 40% av patienter med idiopatisk hörselnedsättning, men det kliniska värdet är tveksamt.
Referenser
- Yamanobe S, Harris JP. Laryngoscope. 1993. Inner ear-specific autoantibodies. PMID: 7680088
- Shin SO et al. Laryngoscope. 1997. Comparison of anti-heat shock protein 70 (anti-hsp70) and anti-68-kDa inner ear protein in the sera of patients with Meniere's disease. PMID: 9023247
- Moscicki RA et al. JAMA. 1994. Serum antibody to inner ear proteins in patients with progressive hearing loss. Correlation with disease activity and response to corticosteroid treatment. PMID: 8057517
- Hirose K et al. Laryngoscope. 1999. Utility of laboratory testing in autoimmune inner ear disease. PMID: 10569401
Senast uppdaterat: 2024-08-12