INDIVIDUAL TEST 095
HSP-70 Antibodies
Note: We are currently experiencing delivery delays for the HSP-70 antibody reagent kit; therefore, the reporting turnaround time is expected to be prolonged. We will resume testing as soon as the reagent kit becomes available (expected in January 2026).
Indication
Suspicion of autoimmune hearing loss
Sample material
Serum
- Minim. volume: 0.5 mL
Transport
Within Sweden
- room temperature
International
- cold
Method
Immunoblot
Reference interval
Negative
Result
Results are reported as negative or positive.
Interpretation
Antibodies against HSP-70 have been reported to occur in up to 40% of patients with idiopathic hearing loss, but the clinical value is unclear.
References
- Yamanobe S, Harris JP. Laryngoscope. 1993. Inner ear-specific autoantibodies. PMID: 7680088
- Shin SO et al. Laryngoscope. 1997. Comparison of anti-heat shock protein 70 (anti-hsp70) and anti-68-kDa inner ear protein in the sera of patients with Meniere's disease. PMID: 9023247
- Moscicki RA et al. JAMA. 1994. Serum antibody to inner ear proteins in patients with progressive hearing loss. Correlation with disease activity and response to corticosteroid treatment. PMID: 8057517
- Hirose K et al. Laryngoscope. 1999. Utility of laboratory testing in autoimmune inner ear disease. PMID: 10569401
Last updated: 2025-12-19
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ENSKILD ANALYS 095
HSP-70-antikroppar
OBS! Vi har för närvarande leveransförseningar av kit för analys av HSP-70-antikroppar, vilket innebär risk för förlängda svarstider. Vi kommer att påbörja analysen så snart nya kit är tillgängliga (förväntas under januari 2026).
Indikation
Misstanke om autoimmun hörselnedsättning
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
Inom Sverige
- rumstemperatur
Internationellt
- kylt
Metod
Immunoblot
Referensintervall
Negativt
Resultat
Resultat anges som negativt eller positivt.
Tolkning
Antikroppar mot HSP-70 har rapporterats förekomma hos upp till 40% av patienter med idiopatisk hörselnedsättning, men det kliniska värdet är tveksamt.
Referenser
- Yamanobe S, Harris JP. Laryngoscope. 1993. Inner ear-specific autoantibodies. PMID: 7680088
- Shin SO et al. Laryngoscope. 1997. Comparison of anti-heat shock protein 70 (anti-hsp70) and anti-68-kDa inner ear protein in the sera of patients with Meniere's disease. PMID: 9023247
- Moscicki RA et al. JAMA. 1994. Serum antibody to inner ear proteins in patients with progressive hearing loss. Correlation with disease activity and response to corticosteroid treatment. PMID: 8057517
- Hirose K et al. Laryngoscope. 1999. Utility of laboratory testing in autoimmune inner ear disease. PMID: 10569401
Senast uppdaterat: 2025-12-19