DIAGNOSTIC TEST 837

Alpha-Enolase Antibodies

Diagnostic test for antibodies against Alpha-Enolase. For suspicion of paraneoplastic retinopathy (Carcinoma Associated retinopathy CAR).

Indication

Suspicion of paraneoplastic retinopathy (Carcinoma Associated Retinopathy, CAR)

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

Western blot

Reference interval

Negative

Result

Results are reported as negative or positive.

Interpretation

Alpha-enolase antibodies are detected in paraneoplastic retinopathy (Carcinoma Associated Retinopathy, CAR) which is associated with melanoma.

These autoantibodies are believed to inhibit the catalytic function of alpha-enolase and increase intracellular ATP, resulting in the destruction of retinal neurons.

References

  • Adamus G et al. Clin Immunol. 2020. Occurrence of major anti-retinal autoantibodies associated with paraneoplastic autoimmune retinopathy. PMID: 31770612
  • Kang L, Wan C. J Neurol. 2022. Paraneoplastic syndrome in neuroophthalmology. PMID: 35779086

Included in these panels

Need pricing information?

Get a quote

How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-11-25