Metabolic Therapeutics Evaluation

Metabolic diseases such as obesity, type 2 diabetes, and related cardiometabolic disorders are among the most pressing healthcare challenges worldwide. With the prevalence of metabolic diseases rising, there is an urgent need for innovative therapies that deliver meaningful clinical outcomes.

Incretin-based therapeutics have redefined the treatment landscape and transformed patient care while demonstrating benefits across a growing range of conditions. As metabolic therapeutics evolve into increasingly complex, multi-target approaches, developers need consistent and flexible tools to investigate the biological activity of drug candidates  across multiple targets, pathways, and modalities.

How We Can Help

Developing next-generation metabolic therapeutics requires more than target engagement data alone. Researchers need biologically relevant functional assays that help characterize candidate molecules, understand mechanism of action, compare therapeutic modalities, and generate robust potency data throughout development.

The iLite^® Metabolic Panel provides a modular set of high-performance cell-based reporter assays specifically designed for the development of next-generation therapeutics for obesity, diabetes, and other metabolic diseases.

Built around key incretin and other metabolic targets, the iLite Metabolic Panel enables assessment of individual or combinations of targets, generating comparable functional data across pathways to support next-generation multi-agonist development.

Support across the metabolic drug development continuum

From discovery through to late-stage development, functional characterization is critical for selecting and advancing the most promising therapeutic candidates.

• Discovery & Lead Optimization. Generate biologically relevant functional data to identify and prioritize candidates with the desired activity profile.

• Candidate Characterization. Compare single-, dual-, and multi-agonist molecules across relevant metabolic targets to better understand their functional properties and differentiation potential.

• Mechanism of Action Studies. Investigate pathway-specific activity using reporter assays designed to reflect relevant biological signalling.

• Potency Assessment & Late-Stage Development. Leverage sensitive and reproducible assays for potency testing, assay transfer, validation, and QC applications.