DIAGNOSTIC TEST PANEL 510
Antiphospholipid Syndrome (APS)
Diagnostic test panel for antibodies against Cardiolipin (IgG, IgM) and Beta-2-Glycoprotein 1 (IgG, IgM). For suspicion of antiphospholipid syndrome.
Indication
Suspicion of antiphospholipid syndrome. Thromboembolism in patients without other risk factors. Unexplained prolonged APT time. Repeated spontaneous abortions.
Clinical background
Antiphospholipid syndrome (APS) is characterized in the patient by thromboses in the larger arteries and veins and thrombotic microangiopathy. Common manifestations are deep vein thrombosis, thrombocytopeny and neurological symptoms or repeated spontaneous abortions. APS occurs in up to a third of patients with lupus erythematosus. Diagnostic criteria suggested for APS are at least one clinical manifestation of thromboembolism or pregnancy complication and at least one laboratory criterion, see below. The increased tendency to thrombosis formation is due to the presence of antibodies against phospholipids, which can inhibit both pro- and anticoagulative components of the coagulation system. In vitro the antibodies inhibit the phospholipiddependent coagulation factors, which leads to a prolonged APT time.
Laboratory tests for antiphospholipid syndrome
Lupus anticoagulans: (Performed in clinical chemistry laboratories with different methods.) Detection of prolonged APT time that is not due to lack of individual coagulation factors and that is restored by adding phospholipids to the sample. Anti-cardiolipin: Cardiolipin is a phospholipid. Antibodies against cardiolipin occur in APS and in up to 30% of patients with SLE. Anti-cardiolipin occurs in some percentage of healthy controls and it is not clear what the clinical significance is. In SLE, however, more than half the patients with anti-cardiolipin develop APS. Anti-cardiolipin also occurs in certain infections, like borreliosis, syphilis, and malaria. In this case it is not associated with APS.
Anti-b2-glycoprotein 1: b-2glycoprotein 1 is a cofactor of cardiolipin in the coagulation cascade. Anti-b2-glycoprotein is more specific than anti-cardiolipin, as it does not occur in infectious conditions.
Tests included in panel
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How to order
This test panel is available worldwide for hospitals, clinics, and physicians.
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Print and complete the request form
Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. -
Prepare your samples
Serum: At least 0.5 mL serum (plain serum tubes without additives).
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Send samples and request form
Within Sweden
Samples can be sent at room temperature to:
Envelopes and smaller boxes:
Wieslab AB, Box 50117, 20211 Malmö, Sweden
Larger boxes and frozen samples:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
International
Samples can be sent at room temperature to:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
Last updated: 2025-08-18
