DIAGNOSTIC TEST 517

Beta-2-Glycoprotein 1 Antibodies (IgG, IgM)

Diagnostic test for antibodies against Beta-2-Glycoprotein 1 (IgG, IgM). For suspected primary antiphospholipid syndrome (APS) and systemic lupus erythematosus with secondary APS.

Indication

Suspicion of primary antiphospholipid syndrome (APS) and systemic lupus erythematous with secondary antiphospholipid syndrome (APS)

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

ELISA

Reference interval

< 20 U/mL negative

Result

Results are reported as negative or positive with a concentration (U/mL).

Interpretation

Elevated levels of IgM and IgG antibodies against Beta-2-Glycoprotein-1 are included in the laboratory criteria for the antiphospholipid syndrome (APS), characterized by thrombotic tendency (arterial and/or venous), and/or pregnancy morbidity (miscarriage/preeclampsia/placental insufficiency).

The syndrome can be associated with SLE (secondary APS) but also occurs without signs of inflammatory systemic disease (primary APS). The highest risk for APS is triple positivity, i.e., the presence of antibodies against Beta-2-Glycoprotein-1 in combination with lupus anticoagulant and antibodies against Cardiolipin.

References

  • Barbhaiya M et al. Ann Rheum Dis. 2023. 2023 ACR/EULAR antiphospholipid syndrome classification criteria. PMID: 37640450
  • Cabrera-Marante O et al. Front Immunol. 2025. Criteria and non-criteria anti-phospholipid antibodies in the different clinical forms of antiphospholipid syndrome. PMID: 40821829
  • Van Hoovels L et al. J Thromb Haemost. 2025. Multicenter study to improve clinical interpretation of anticardiolipin and anti-β2-glycoprotein I antibody test results for diagnosis of antiphospholipid syndrome. PMID: 40383153

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-12-01