DIAGNOSTIC TEST 294
ApoE4 Genotyping
Diagnostic test for ApoE4. For suspected Alzheimer's Disease.
Indication
Suspicion of Alzheimer’s Disease
Sample material
EDTA whole blood
- Minim. volume: 3 mL
Transport
- Within Sweden: room temperature
- International: room temperature
Method
NAA (Nucleic Acid Amplification), Sanger sequensing
Please note that the request must be completed with a signed informed consent form.
Reference interval
Negative – No copies of the gene
Result
Results are reported as negative, heterozygote, or homozygote.
Interpretation
The apolipoprotein E (ApoE) is a ligand of the LDL receptor and plays an important role in the regulation of cholesterol and triglyceride homeostasis. There are three gene variants of ApoE (2, 3, and 4).
The ApoE4 gene is associated with an increased risk for developing the non-familial late-onset form of Alzheimer's disease. Compared to the normal population, heterozygous ApoE4 carriers have a 4-fold increased risk and homozygous ApoE4 carriers about 10-fold increased risk of developing Alzheimer's disease.
References
- Hales CM. Med Clin North Am. 2025. Alzheimer's Disease Diagnosis and Management in the Age of Amyloid Monoclonal Antibodies. PMID: 39893023
- Raulin AC et al. Mol Neurodegener. 2022. ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies. PMID: 36348357
Included in these panels
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How to order
This test is only available as part of a test panel.
Last updated: 2026-09-14
