DIAGNOSTIC TEST 294

ApoE4 Genotyping

Diagnostic test for ApoE4. For suspected Alzheimer's Disease.

Indication

Suspicion of Alzheimer’s Disease

Sample material

EDTA whole blood

  • Minim. volume: 3 mL

Transport

  • Within Sweden: room temperature
  • International: room temperature

Method

NAA (Nucleic Acid Amplification), Sanger sequensing

Please note that the request must be completed with a signed informed consent form.

Reference interval

Negative – No copies of the gene

Result

Results are reported as negative, heterozygote, or homozygote.

Interpretation

The apolipoprotein E (ApoE) is a ligand of the LDL receptor and plays an important role in the regulation of cholesterol and triglyceride homeostasis. There are three gene variants of ApoE (2, 3, and 4).

The ApoE4 gene is associated with an increased risk for developing the non-familial late-onset form of Alzheimer's disease. Compared to the normal population, heterozygous ApoE4 carriers have a 4-fold increased risk and homozygous ApoE4 carriers about 10-fold increased risk of developing Alzheimer's disease.

References

  • Hales CM. Med Clin North Am. 2025. Alzheimer's Disease Diagnosis and Management in the Age of Amyloid Monoclonal Antibodies. PMID: 39893023
  • Raulin AC et al. Mol Neurodegener. 2022. ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies. PMID: 36348357

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. Genetic testing also requires a sigend consent form.

  2. Prepare your samples

    Whole blood: At least 3 mL blood (EDTA tubes).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-12-05