DIAGNOSTIC TEST PANEL 557

Alzheimer's Disease Biomarkers – Extended Analysis

Diagnostic test panel for ApoE4 and pTau217. For suspicion of Alzheimer's disease.

Indication

Suspicion of Alzheimer's disease

Sample material

EDTA whole blood (ApoE4)

Minim. volume: 3mL

EDTA-plasma (pTau217)

Minim. volume: 0,5 mL

Transport

Within Sweden: EDTA whole blood room temperature and EDTA-plasma frozen

International: EDTA whole blood room temperature and EDTA-plasma frozen

Clinical background

Alzheimer's Disease (AD) is a progressive neurological disease. AD is generally characterized by widespread deposition of amyloid beta (amyloid-β) plaques outside neurons and aggregation of abnormally phosphorylated tau proteins (p-tau) within neurons. These changes are associated with damage and loss of neurons in various parts of the brain. The biological mechanisms that lead to neuronal damage develop years before the onset of clinical symptoms.

Diagnosis entails a comprehensive examination including medical history, cognitive assessments, physical examination, neurological evaluation, and analysis of biomarkers and genotyping.

  • Apolipo protein E (ApoE) is a ligand of the LDL receptor and plays an important role in the regulation of cholesterol and triglyceride homeostasis. There are three gene variants of ApoE (2, 3, and 4).
  • The ApoE4 gene is associated with an increased risk for developing the non-familial late-onset form of Alzheimer's disease. Compared to the normal population, heterozygous ApoE4 carriers have a 4-fold increased risk and homozygous ApoE4 carriers about 10-fold increased risk of developing Alzheimer's disease.
  • The level of phosphorylated Tau 217 (pTau217) in blood is associated with the pathological processes in Alzheimer's disease. The pTau217 level may therefore be useful as a biomarker in the investigation of cognitive impairment.

Tests included in panel

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How to order

This test panel is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. If you are a new customer, please also include a completed customer information form. Genetic testing also requires a sigend consent form.

  2. Prepare your samples

    EDTA Plasma: At least 0.5 mL blood plasma (EDTA tubes).
    Whole blood: At least 3 mL blood (EDTA tubes).

  3. Send samples and request form

    Within Sweden
    Send samples frozen to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples frozen to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Last updated: 2026-10-01