DIAGNOSTIC TEST PANEL 557
Alzheimer's Disease Biomarkers – Extended Analysis
Diagnostic test panel for ApoE4, Neurogranin, and pTau-181. For suspicion of Alzheimer's disease.
Indication
Suspicion of Alzheimers disease
This panel requires blood, plasma and CSF.
Clinical background
Alzheimer's Disease (AD) is a progressive neurological disease. AD is generally characterized by widespread deposition of amyloid beta (amyloid-β) plaques outside neurons and aggregation of abnormally phosphorylated tau proteins (p-tau) within neurons. These changes are associated with damage and loss of neurons in various parts of the brain. The biological mechanisms that lead to neuronal damage develop years before the onset of clinical symptoms.
Diagnosis entails a comprehensive examination including medical history, cognitive assessments, physical examination, neurological evaluation, analysis of biomarkers and genotyping.
- Apolipo protein E (ApoE) is a ligand of the LDL receptor and plays an important role in the regulation of cholesterol and triglyceride homeostasis. There are three gene variants of ApoE (2, 3, and 4). Compared to the normal population, heterozygous ApoE4 carriers have a 4-fold increased risk and homozygous ApoE4 carriers about 10-fold increased risk of developing Alzheimer's disease.
- Tau proteins phosphorylated at threonine 181 (pTau-181). Tau (tubulin-associated unit) is a protein primarily expressed on the axons of neurons where it regulates microtubule dynamics and transport of organelles. The functions of Tau are regulated by phosphorylation. Hyperphosphorylation of Tau is a step in the formation of neurofibrillary tangles. Increased levels in plasma are detected in early pathological changes and correlated to clinical severity of disease in AD.
- The postsynaptic protein Neurogranin is important for memory creation and function. Elevated levels can be detected at the early stages of the degenerative process. Alzheimer’s patients show increased levels of neurogranin compared to those of other neurogenerative diseases.
Tests included in panel
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How to order
This test panel is available worldwide for hospitals, clinics, and physicians.
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Print and complete the request form
Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. Genetic testing also requires a sigend consent form. -
Prepare your samples
EDTA Plasma: At least 0.5 mL blood plasma (EDTA tubes).
CSF: At least 0.5 mL CSF (polypropylene tubes).
Whole blood: At least 3 mL blood (EDTA tubes).
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Send samples and request form
Within Sweden
Send samples frozen to:
Envelopes and smaller boxes:
Wieslab AB, Box 50117, 20211 Malmö, Sweden
Larger boxes and frozen samples:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
International
Send samples frozen to:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
Last updated: 2025-08-18
