DIAGNOSTIC TEST 851

DPPX Antibodies  (IgG)

Diagnostic test for antibodies against DPPX. For suspicion of autoimmune encephalitis.

Indication

Suspicion of autoimmune encephalitis

Sample material

Serum

  • Minim. volume: 0,5 mL

CSF

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

Cell-based assay (CBA), Indirect immunofluorescence (IIF)

Reference interval

Serum: <1:10 negative

CSF: negative

Result

Results are reported as negative or positive. A positive result is followed by a titer (serum).

Interpretation

DPPX interacts with the potassium channel KV4 and regulates membrane excitability in hippocampal CA1 pyramidal cells. Antibodies against DPPX can cause autoimmune encephalitis.

Antibodies against DPPX are graded as Lower-risk antibodies with a frequency of <10% of underlying cancer and a positive result yields 0 points PNS score, according to Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes.

References

  • Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
  • Kerstens J et al. Neurol Neuroimmunol Neuroinflamm. 2024. Autoimmune Encephalitis and Paraneoplastic Neurologic Syndromes: A Nationwide Study on Epidemiology and Antibody Testing Performance. PMID: 39467237
  • de Bruijn MAAM et al. Nat Rev Dis Primers. 2025. Autoimmune encephalitis. PMID: 40935848
  • Cleaver J et al. J Infect. 2025. Clinical phenotype and outcomes in autoimmune encephalitis after herpes simplex virus encephalitis: A systematic review and meta-analysis. PMID: 40780589

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. If you are a new customer, please also include a completed customer information form.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).
    CSF: At least 0.5 mL CSF (polypropylene tubes).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Last updated: 2026-09-21