DIAGNOSTIC TEST 002

GBM Antibodies (IgG)

Diagnostic test for antibodies against GBM. For suspicion of Goodpasture syndrome.

Indication

Suspicion of Goodpasture syndrome

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

FEIA (fluoroenzyme immunoassay)

Reference interval

< 7 U/mL negative, 7–10 U/mL borderline

Result

Results are reported as negative, borderline, or positive with a concentration.

Interpretation

Goodpasture syndrome is characterized by a rapidly progressive glomerulonephritis. Lung commitment with bleeding is also common. The antibodies target the type IV collagen of the basal membranes of the glomeruli and lung capillaries. Early diagnosis and a prompt treatment are crucial to avoid irreversible tissue damage. The antibody levels can be used to monitor treatment effect.

If suspicion of Goodpasture syndrome remains despite a borderline result, then subtyping determination of IgG4-antibodies against GBM is recommended. Contact the laboratory if this test is wished.

References

  • Hudson BG et al. N Engl J Med. 2003. Alport's syndrome, Goodpasture's syndrome, and type IV collagen. PMID: 12815141
  • Segelmark M et al. Nephron Clin Pract. 2003. The prognostic significance in Goodpasture's disease of specificity, titre and affinity of anti-glomerular-basement-membrane antibodies. PMID: 12902632
  • Rovin BH et al. Kidney Int. 2021. Executive summary of the KDIGO 2021 Guideline for the Management of Glomerular Diseases. PMID: 34556300

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-12-10