DIAGNOSTIC TEST 868

KCNA2 Antibodies (IgG)

Diagnostic test for antibodies against KCNA2. For suspected Autoimmune encephalitis or Atypical dementia.

Indication

Suspicion of autoimmune encephalitis or atypical dementia

Sample material

Serum

  • Minim. volume: 0,5 mL

CSF

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

Cell-based assay (CBA), Indirect immunofluorescence(IIF).

Reference interval

Serum: <1:10 negative

CSF: negative

Result

Results are reported as negative or positive. A positive result is followed by a titer (serum).

Interpretation

Autoantibodies against the potassium voltage-gated channel subfamily A 2 subunit (KCNA2), have been found in patients suffering from cognitive impairment, memory disturbance, and neuropsychiatric symptoms. Epileptic seizures, gait disorder, and ataxia have also been described.

Patients positive for antibodies against KCNA2 in CSF are more likely to suffer from cognitive impairment compared to seropositive patients.

References

  • Arlt FA et al. Brain Behav Immun. 2024. KCNA2 IgG autoimmunity in neuropsychiatric diseases. PMID: 38309639.
  • Timäus C et al. Brain Sci. 2021. KCNA2 Autoimmunity in Progressive Cognitive Impairment: Case Series and Literature Review. PMID: 33445475.

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. If you are a new customer, please also include a completed customer information form.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).
    CSF: At least 0.5 mL CSF (polypropylene tubes).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Last updated: 2026-09-23