DIAGNOSTIC TEST 118
mGluR5 Antibodies (IgG)
Diagnostic test for antibodies against mGlur5. For suspicion of autoimmune encephalitis.
Indication
Suspicion of autoimmune encephalitis
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
Cell-based assay (CBA), indirect immunofluorescence (IIF)
Reference interval
<1:10 negative
Result
Results are reported as negative or positive with a titer.
Interpretation
Antibodies against mGluR5 may occur in autoimmune encephalitis characterized by neuropsychiatric symptoms (Ophelia syndrome), and are associated with Hodgkin lymphoma.
References
- Ancona C et al. Front Pediatr. 2022. Autoimmune Encephalitis and Other Neurological Syndromes With Rare Neuronal Surface Antibodies in Children: A Systematic Literature Review. PMID: 35515348
- Spatola M et al. Neurology. 2018. Encephalitis with mGluR5 antibodies: Symptoms and antibody effects. PMID: 29703767
- Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
- Salles PA et al. Mov Disord Clin Pract. 2024. mGlur5 Encephalitis Causing Myoclonus-Ataxia Syndrome and Psychosis: A Case Report. PMID: 38923251
Included in these panels
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How to order
This test is available worldwide for hospitals, clinics, and physicians.
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Print and complete the request form
Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. -
Prepare your samples
Serum: At least 0.5 mL serum (plain serum tubes without additives).
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Send samples and request form
Within Sweden
Samples can be sent at room temperature to:
Envelopes and smaller boxes:
Wieslab AB, Box 50117, 20211 Malmö, Sweden
Larger boxes and frozen samples:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
International
Send samples cold to:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
Last updated: 2025-12-05
