DIAGNOSTIC TEST PANEL 574
Ophelia’s Syndrome (Paraneoplastic Cerebellar Ataxia or Limbic Encephalitis)
Diagnostic test panel for antibodies against mGlur1, mGlur5. For suspicion of Ophelia's Syndrome.
Indication
Suspicion of Ophelia's Syndrome
Clinical background
Diagnosis of this disorder is important since it can affect young individuals and is treatable.
Metabotropic glutamate receptors are transmembrane proteins in neuronal membranes. Unlike ionotropic receptors, metabotropic glutamate receptors (mGluRs) are not ion channels. Instead, they activate biochemical cascades, leading to the modification of other proteins, as for example ion channels.
- Antibodies against mGluR1 (metabotropic glutamate receptor 1) have been described for Morbus Hodgkin together with (paraneoplastic) cerebellar ataxia.
- Antibodies against mGluR5 (metabotropic glutamate receptor 5) have been reported in limbic encephalitis with (or without) Hodgkin's lymphoma (Ophelia's syndrome).
It is recommended to use the test on serum. It has not been reported cases of only CSF positive.
References
Read "Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes" (open access)
Tests included in panel
Need pricing information?
How to order
This test panel is available worldwide for hospitals, clinics, and physicians.
-
Print and complete the request form
Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. -
Prepare your samples
Serum: At least 0.5 mL serum (plain serum tubes without additives).
-
Send samples and request form
Within Sweden
Samples can be sent at room temperature to:
Envelopes and smaller boxes:
Wieslab AB, Box 50117, 20211 Malmö, Sweden
Larger boxes and frozen samples:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
International
Send samples cold to:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
Last updated: 2025-08-18
