DIAGNOSTIC TEST 960
MuSK Antibodies (IgG)
Diagnostic test for antibodies against MuSK. For suspicion of myasthenia gravis.
Indication
Suspicion of Myasthenia Gravis (MG)
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
RIA
Reference interval
< 0.05 nmol/L negative
Result
Results are reported as negative or positive with a concentration.
Interpretation
Antibodies against MuSK are seen in approximately 40% of patients with myasthenia gravis (MG) lacking AChR antibodies. MuSK is a membrane protein in motor end plates and is important for the structure and function of AChR.
Wieslab also offers a test for antibodies against LRP4 which can be seen in 1-5% of patients with MG as well as in double-negative MG, i.e., without the presence of antibodies against AChR or MuSK.
References
- Skeie GO et al. J Neurol. 2010. Guidelines for treatment of autoimmune neuromuscular transmission disorders. PMID: 20402760
- Fichtner ML et al. Int Rev Neurobiol. 2025. Autoantibodies in myasthenia gravis. PMID: 40675742
- Keritam O et al. Front Immunol. 2024. A clinical perspective on muscle specific kinase antibody positive myasthenia gravis. PMID: 39703505
Included in these panels
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How to order
This test is available worldwide for hospitals, clinics, and physicians.
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Print and complete the request form
Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. -
Prepare your samples
Serum: At least 0.5 mL serum (plain serum tubes without additives).
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Send samples and request form
Within Sweden
Samples can be sent at room temperature to:
Envelopes and smaller boxes:
Wieslab AB, Box 50117, 20211 Malmö, Sweden
Larger boxes and frozen samples:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
International
Send samples cold to:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
Last updated: 2025-10-09
