DIAGNOSTIC TEST PANEL 543
Myasthenia Gravis
Diagnostic test panel for antibodies against AChR, Lrp4, MuSK, and Titin. For suspicion of myasthenia gravis or thymoma.
Indication
Suspicion of myasthenia gravis or thymoma.
Clinical background
Myasthenia gravis (MG) is an autoimmune neuromuscular disorder that is caused by a disruption of impulse transmission from the nerve to the muscle. MG is characterized by weakness and fatigue in the skeletal muscle. The most common form of MG is seen in approximately 85% of patients and is caused by antibodies to nicotinergic acetylcholine receptors (AChR) on the muscle membrane. The antibodies formed against AChR partially increase receptor metabolism and partially destroy the receptors by means of complement. When the AChR has decreased to about one-third on the muscle end plate, patients experience fatigue symptoms.
The second large group of antibodies, antibodies against muscle-specific tyrosine kinase (MuSK), is seen in approximately 40% of patients lacking AChR antibodies. MuSK is a membrane protein in motor end plates and is important for the structure and function of AChR. In a few patients, both forms of antibodies may occur. The recommended analysis procedure is that negative test results for anti-AChR are complemented with anti-MuSK.
Antibodies against titin and striated muscle may sometimes be detected in patients with myasthenia gravis and are associated with an increased incidence of thymoma. Antibodies against low-density lipoprotein receptor-related protein 4 (LRP4) have been detected in 2-50% of triple seronegative MG patients (that lack both AChR and Musk antibodies). A majority of these patients have ocular disease or mild generalized MG.
Tests included in panel
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How to order
This test panel is available worldwide for hospitals, clinics, and physicians.
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Print and complete the request form
Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. -
Prepare your samples
Serum: At least 1 mL serum (plain serum tubes without additives).
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Send samples and request form
Within Sweden
Samples can be sent at room temperature to:
Envelopes and smaller boxes:
Wieslab AB, Box 50117, 20211 Malmö, Sweden
Larger boxes and frozen samples:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
International
Send samples cold to:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
Last updated: 2025-08-18
