DIAGNOSTIC TEST 119

Neurofilament Heavy Chain (pNfH)

Diagnostic test for pNfH. For suspicion of progressive ALS (amyotrophic lateral sclerosis).

Indication

Suspicion of progressive ALS (amyotrophic lateral sclerosis)

Sample material

CSF

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: frozen
  • International: frozen

Method

ELISA

Reference interval

< 0.69 ng/mL normal, 0.69-1.52 ng/mL borderline

Result

Results are reported as normal, borderline or increased with a concentration (ng/mL).

Interpretation

Increased pNfH levels indicate neuronal/axonal damage in the central nervous system and correlates with levels of neurofilament light chain (NfL). High levels have been reported in ALS (amyotrophic lateral sclerosis) and support the diagnosis and prediction of disease progression.

References

  • Behzadi A et al. Sci Rep. 2021. Neurofilaments can differentiate ALS subgroups and ALS from common diagnostic mimics. PMID: 34764380
  • Mondesert E et al. Neurology. 2025. Comparative Performances of 4 Serum NfL Assays, pTau181, and GFAP in Patients With Amyotrophic Lateral Sclerosis. PMID: 40009787

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    CSF: At least 0.5 mL CSF (polypropylene tubes).

  3. Send samples and request form

    Within Sweden
    Send samples frozen to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples frozen to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-11-25