DIAGNOSTIC TEST PANEL 565
Neuromyelitis Optica Spectrum Disorder (NMOSD)/MOGAD
Diagnostic test panel for antibodies against AQP4 and MOG. For suspicion of multiple sclerosis (MS), Neuromyelitis optica spectrum disorder (NMOSD) or MOG-associated disease (MOGAD).
Available as urgent test with results within 24 h.
Indication
Suspicion of Neuromylelits Optica Spectrum Disorder (NMOSD)/ MOG-associated disease (MOGAD)
Sample material
Serum
- Minim. volume: 0,5 mL
CSF
- Minim. volume: 0,5 mL
Transport
Within Sweden
- room temperature
International
- cold
Clinical background
Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory, demyelinating disease in the central nervous system. The main characteristics of NMOSD are recurrent episodes of optic neuritis or acute myelitis.
The area postrema syndrome, characterized by episodes of intractable hiccups and problems with nausea and vomiting, frequently precedes the onset of optical neuritis or myelitis in patients with antibodies against AQP4. Previously classified as a variant of Multiple Sclerosis (MS), NMOSD is now recognized as a distinct entity.
Most patients suffering from NMOSD test positive for AQP4 antibodies, but a subset instead has MOG antibodies and is diagnosed with Myelin Oligodendrocyte Glycoprotein Antibody Disease (MOGAD). While NMOSD and MOGAD share clinical characteristics, their pathogenesis and disease courses often differ significantly. Accurate differential diagnosis from MS is crucial since both NMOSD and MOGAD require different treatment approaches.
For patients presenting with any of these symptoms, it is recommended that serologic workups include both MOG and AQP4 antibody testing using cell-based assays (CBA). In rare cases, both AQP4 and MOG antibodies can be detected, but if these cases represent a specific phenotype, it is not known.
Tests included in panel
Need pricing information?
How to order
This test panel is available worldwide for hospitals, clinics, and physicians.
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Print and complete the request form
Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. -
Prepare your samples
Serum: At least 0.5 mL serum (plain serum tubes without additives).
CSF: At least 0.5 mL CSF (polypropylene tubes).
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Send samples and request form
Within Sweden
Samples can be sent at room temperature to:
Envelopes and smaller boxes:
Wieslab AB, Box 50117, 20211 Malmö, Sweden
Larger boxes and frozen samples:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
International
Samples can be sent at room temperature to:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
Last updated: 2025-08-18
