DIAGNOSTIC TEST 884

MOG Antibodies (IgG)

Diagnostic test for antibodies against MOG. For suspicion of MOG-associated disease (MOGAD).

Indication

Suspicion of Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disease (NMOSD) or MOG-associated disease (MOGAD)

Sample material

Serum

  • Minim. volume: 0,5 mL

CSF

  • Minim. volume: 0,5 mL

Transport

Within Sweden

  • room temperature

International

  • cold

Method

Cell-based assay (CBA), indirect immunofluorescence (IIF)

Reference interval

  • Serum: <1:10 negative
  • CSF: negative

Result

Results are reported as negative or positive. A positive result is followed by a titer (serum).

Interpretation

The presence of IgG-antibodies against MOG is associated with MOG associated disease (MOGAD). In MOGAD, antibodies against MOG can usually be detected in both serum and CSF, but in 10-20% of cases only in either serum or CSF.

If clinical suspicion of MOGAD remains after a negative result, complementary analysis with live Cell Based Assay (live CBA) is recommended in serum.

References

  • Sato DK et al. Neurology. 2014. Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders. PMID: 24415568
  • Reindl M et al. Neurol Neuroimmunol Neuroinflamm. 2020. International multicenter examination of MOG antibody assays. PMID: 32024795
  • Majed M et al. Neurol Neuroimmunol Neuroinflamm. 2016. Clinical utility of testing AQP4-IgG in CSF: Guidance for physicians. PMID: 27144221
  • Höftberger R et al. Mult Scler. 2015. Antibodies to MOG and AQP4 in adults with neuromyelitis optica and suspected limited forms of the disease. PMID: 25344373
  • Wingerchuk DM et al. Neurology. 2015. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. PMID: 26092914
  • Lycke J, Malmeström C. Lakartidningen. 2010. Neuromyelitis optica--viktig differentialdiagnos till MS. Tidigt insatt behandling avgörande för prognosen. PMID: 21294335
  • Banwell B et al. Lancet Neurol. 2023. Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria. PMID: 36706773
  • Paul F et al. Neurol Neuroimmunol Neuroinflamm. 2023. International Delphi Consensus on the Management of AQP4-IgG+ NMOSD: Recommendations for Eculizumab, Inebilizumab, and Satralizumab. PMID: 37258412
  • Petzold A et al. Lancet Neurol. 2022. Diagnosis and classification of optic neuritis. PMID: 36179757

Included in these panels

Need pricing information?

Get a quote

How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).
    CSF: At least 0.5 mL CSF (polypropylene tubes).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-08-18