DIAGNOSTIC TEST 742

Zic4 Antibodies (IgG)

Diagnostic test for antibodies against Zic4. For suspicion of paraneoplastic syndrome.

swedac

Accredited. View certificate [.pdf]

Indication

Suspicion of paraneoplastic syndrome

Sample material

Serum

  • Minim. volume: 0,5 mL

CSF

  • Minim. volume: 2,0 mL

Transport

Within Sweden

  • room temperature

International

  • cold

Method

Immunoblot

Reference interval

Serum

  • ≤5 negative

CSF

  • negative

Result

Serum

  • results are reported as negative, borderline, or positive with an intensity value.

CSF

  • results are reported as negative, borderline, or positive.

Interpretation

Antibodies against Zic4 may occur with paraneoplastic neurological disease associated with small-cell lung cancer with or without neurological symptoms. Most Zic4-positive patients also produce antibodies against Hu and CV2. Patients who have only Zic4 antibodies usually display symptoms of cerebellar degeneration. Patients with a combination of Zic4 and other autoantibodies suffer from a broader spectrum of symptoms.

References

  • Rosenfeld MR, Dalmau J. Neurol Clin. 2018. Paraneoplastic Neurologic Syndromes. PMID: 30072076
  • Balint B et al. Brain. 2018. Movement disorders with neuronal antibodies: syndromic approach, genetic parallels and pathophysiology. PMID: 29053777
  • Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
  • Garza M, Piquet AL. Front Neurol. 2021. Update in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia. PMID: 34489848

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).
    CSF: At least 2 mL CSF (polypropylene tubes).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-08-18