INDIVIDUAL TEST 011
PR3-ANCA (IgG)
Indication
Suspicion of systemic vasculitis and follow-up of patients with vasculitis
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: room temperature
Method
FEIA (fluoroenzymeimmunoassay), sensitive
Reference interval
< 2.0 IU/mL negative, 2.0-3.0 IU/mL borderline
Result
Results are reported as negative, borderline, or positive with a concentration.
Interpretation
PR3-ANCA is a strong marker for the vasculitis disease granulomatosis with polyangiitis (GPA) (Wegener granulomatosis), the levels are usually higher than borderline in these cases. In the active phase of the disease about 90% of the patients are positive for PR3-ANCA. Antibody levels often decrease when the disease is in remission, while a rising level may indicate a relapse. Low levels of antibodies can be detected in infections without relation to vasculitis.
References
- Neumann I et al. Nephrol Dial Transplant. 2003. Glomerular immune deposits are associated with increased proteinuria in patients with ANCA-associated crescentic nephritis. PMID: 12584274
- Csernok E et al. Rheumatology (Oxford). 2002. A critical evaluation of commercial immunoassays for antineutrophil cytoplasmic antibodies directed against proteinase 3 and myeloperoxidase in Wegener's granulomatosis and microscopic polyangiitis. PMID: 12422006
- Basu N et al. Ann Rheum Dis. 2010. EULAR points to consider in the development of classification and diagnostic criteria in systemic vasculitis. PMID: 20448283.
Last updated: 2025-10-09
Can't find what you're looking for? We are here to help
ENSKILD ANALYS 011
PR3-ANCA (IgG)
Indikation
Misstanke om systemisk vaskulit samt uppföljning av patienter med vaskulit.
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: rumstemperatur
Metod
FEIA (fluoroenzymeimmunoassay), sensitive
Referensintervall
< 2.0 IU/mL negativt, 2.0–3.0 IU/mL gränsvärde
Resultat
Resultatet anges som negativt, gränsvärde eller positivt med koncentration.
Tolkning
PR3-ANCA är en stark markör för vaskulitsjukdomen granulomatos med polyangit (GPA) (Wegeners granulomatos), men då ses vanligen en starkare positiv reaktion. I aktiv fas av sjukdomen har ca 90 % av patienterna positiv PR3-ANCA. Antikroppsnivån minskar ofta i remission, medan en stigande nivå kan förebåda recidiv. Låga nivåer kan ses övergående vid infektion utan koppling till vaskulit.
Referenser
- Neumann I et al. Nephrol Dial Transplant. 2003. Glomerular immune deposits are associated with increased proteinuria in patients with ANCA-associated crescentic nephritis. PMID: 12584274
- Csernok E et al. Rheumatology (Oxford). 2002. A critical evaluation of commercial immunoassays for antineutrophil cytoplasmic antibodies directed against proteinase 3 and myeloperoxidase in Wegener's granulomatosis and microscopic polyangiitis. PMID: 12422006
- Basu N et al. Ann Rheum Dis. 2010. EULAR points to consider in the development of classification and diagnostic criteria in systemic vasculitis. PMID: 20448283.
Senast uppdaterat: 2025-10-09