INDIVIDUAL TEST 015
MPO-ANCA (IgG)
Indication
Suspicion of systemic vasculitis, especially with kidney involvement
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: room temperature
Method
FEIA (fluoroenzyme immunoassay), sensitive
Reference interval
< 3.5 IU/mL negative, 3.5-5.0 IU/mL borderline
Result
Results are reported as negative, borderline, or positive with a concentration (U/mL).
Interpretation
MPO-ANCA is a marker for the vasculitis diseases microscopic polyangiitis (MPA) and eosinophil granulomatosis with polyangiitis (EGPA), previously named Churg-Strauss syndrome. Antibody levels may decrease during remission, and an increasing level may suggest a relapse. MPO-ANCA may also occur in SLE, infections, and drug-induced conditions without relation to vasculitis.
References
- Neumann I et al. Nephrol Dial Transplant. 2003. Glomerular immune deposits are associated with increased proteinuria in patients with ANCA-associated crescentic nephritis. PMID: 12584274
- Csernok E et al. Rheumatology (Oxford). 2002. A critical evaluation of commercial immunoassays for antineutrophil cytoplasmic antibodies directed against proteinase 3 and myeloperoxidase in Wegener's granulomatosis and microscopic polyangiitis. PMID: 12422006
- Basu N et al. Ann Rheum Dis. 2010. EULAR points to consider in the development of classification and diagnostic criteria in systemic vasculitis. PMID: 20448283.
Last updated: 2025-10-09
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ENSKILD ANALYS 015
MPO-ANCA (IgG)
Indikation
Misstanke om systemisk vaskulit, särskilt med njurengagemang
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: rumstemperatur
Metod
FEIA (fluoroenzymeimmunoassay), sensitive
Referensintervall
< 3.5 IU/mL negativt, 3.5–5.0 IU/mL gränsvärde
Resultat
Resultatet anges som negativt, gränsvärde eller positivt med koncentration.
Tolkning
MPO-ANCA är markör för de systemiska vaskulitsjukdomarna mikroskopisk polyangiit (MPA) och eosinofil granulomatos med polyangiit (EGPA) som tidigare benämndes Churg-Strauss syndrom. Antikroppsnivån kan sjunka vid remission och en stigande nivå kan förebåda recidiv. MPO-ANCA kan också förekomma vid SLE, infektioner och vara läkemedelsutlöst utan koppling till vaskulit.
Referenser
- Neumann I et al. Nephrol Dial Transplant. 2003. Glomerular immune deposits are associated with increased proteinuria in patients with ANCA-associated crescentic nephritis. PMID: 12584274
- Csernok E et al. Rheumatology (Oxford). 2002. A critical evaluation of commercial immunoassays for antineutrophil cytoplasmic antibodies directed against proteinase 3 and myeloperoxidase in Wegener's granulomatosis and microscopic polyangiitis. PMID: 12422006
- Basu N et al. Ann Rheum Dis. 2010. EULAR points to consider in the development of classification and diagnostic criteria in systemic vasculitis. PMID: 20448283.
Senast uppdaterat: 2025-10-09