INDIVIDUAL TEST 761

PCA 2 (Purkinje cell antibodies)

IndicationSuspicion of paraneoplastic syndrome.MethodIndirect immunofluorescence.AnswerThe result is given as negative or positive with titer.InterpretationThe antigen PCA-2 (Purkinje cell antigen 2) is found in Purkinje cells, most major neurons and several tumour types, e.g. breast, ovary and SCLC. They often present as encephalomyelitis or cerebellar degeneration.

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ENSKILD ANALYS 761

PCA-2 (Purkinjecells-antikroppar)

Indikation

Misstanke om paraneoplastiskt syndrom.

Metod

Indirekt immunofl ourescence.

Svar

Resultatet anges som negativt eller positivt med titer.

Tolkning

Antigenet PCA-2 finns i purkinjeceller (purkinjecellsantigen 2), de flesta större neuroner och flera tumörtyper som bröst, ovarie, SCLC, thymom samt vid Hodgkins lymfom. Presenterar sig ofta som encephalomyelit eller cerebellär degeneration.

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