INDIVIDUAL TEST 761
PCA-2 Antibodies
Indication
Suspicion of paraneoplastic syndrome
Sample material
Serum
- Minim. volume: 0,5 mL
CSF
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
Indirect immunofluorescence (IIF)
Reference interval
Serum: <1:10 negative
CSF: <1:2 negative
Result
Serum: Results are reported as negative or positive with titer.
CSF: Results are reported as negative or positive.
Interpretation
Purkinje cell antigen 2 (PCA-2) are expressed in neuronal tissue, antibodies directed against PCA-2 can be associated with breast, ovary, and small cell lung cancer (SCLC). Common symptoms are encephalomyelitis and cerebellar degeneration with ataxia.
References
- Dalmau J, Geis C, Graus F. Physiol Rev. 2017. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. PMID: 28298428
- Alexopoulos H, Dalakas MC. J Autoimmun. 2019. The immunobiology of autoimmune encephalitides. PMID: 31611142
- Graus F, et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. May 18;8(4):e1014. PMID: 34006622
Last updated: 2025-11-25
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ENSKILD ANALYS 761
PCA-2-antikroppar
Indikation
Misstanke om paraneoplastiskt syndrom
Provmaterial
Serum
- Minim. volym: 0,5 mL
Likvor
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
Indirekt immunofluorescens (IIF)
Referensintervall
Serum: <1:20 negativt
Likvor: <1:2 negativt
Resultat
Serum: Resultat anges som negativt eller positivt med titer.
Likvor: Resultatet anges som negativt eller positivt.
Tolkning
Purkinjecellsantigen 2 (PCA-2) uttrycks i nervceller och antikroppar mot dessa är associerade med bröst-, ovarial- och småcellig lungcancer (SCLC). Vanliga symptom är encefalomyelit och cerebellär degeneration med ataxi.
Referenser
- Dalmau J, Geis C, Graus F. Physiol Rev. 2017. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. PMID: 28298428
- Alexopoulos H, Dalakas MC. J Autoimmun. 2019. The immunobiology of autoimmune encephalitides. PMID: 31611142
- Graus F, et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. May 18;8(4):e1014. PMID: 34006622
Senast uppdaterat: 2025-11-25