INDIVIDUAL TEST 761
PCA-2 Antibodies
Indication
Suspicion of paraneoplastic syndrome.
Method
Indirect immunofluorescence.
Result
The result is reported as negative or positive with titer.
Interpretation
The antigen PCA-2 (Purkinje cell antigen 2) is found in Purkinje cells, most major neurons and several tumour types, e.g. breast, ovary and SCLC. The symptoms are encephalomyelitis or cerebellar degeneration.
Antibodies against PCA-2 are graded as High-risk antibodies with a frequency of 80% of underlying cancer and a positive result yield 3 points PNS score, according to Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes.
References
- Dalmau J, Geis C, Graus F. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. Physiol Rev. 2017 Apr;97(2):839-887. PMID: 28298428
- Alexopoulos H, Dalakas MC. The immunobiology of autoimmune encephalitides. J Autoimmun. 2019 Nov;104:102339. PMID: 31611142.
- Graus F, et al. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. Neurol Neuroimmunol Neuroinflamm. 2021 May 18;8(4):e1014. PMID: 34006622
Last updated: 2024-07-02
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ENSKILD ANALYS 761
PCA-2-antikroppar
Indikation
Misstanke om paraneoplastiskt syndrom.
Metod
Indirekt immunoflourescence.
Resultat
Resultatet anges som negativt eller positivt med titer.
Tolkning
Antigenet PCA-2 finns i purkinjeceller (purkinjecellsantigen 2), de flesta större neuroner och flera tumörtyper som bröst, ovarie, SCLC, thymom samt vid Hodgkins lymfom. Symptomen är encephalomyelit eller cerebellär degeneration.
Antikropparna riktade mot PCA-2 bedöms vara High-risk antibodies med en förekomst på 80% för en underliggande cancer och positivitet ger 3 poäng i PNS score enligt Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes.
Referenser
- Dalmau J, Geis C, Graus F. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. Physiol Rev. 2017 Apr;97(2):839-887. PMID: 28298428
- Alexopoulos H, Dalakas MC. The immunobiology of autoimmune encephalitides. J Autoimmun. 2019 Nov;104:102339. PMID: 31611142.
- Graus F, et al. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. Neurol Neuroimmunol Neuroinflamm. 2021 May 18;8(4):e1014. PMID: 34006622
Senast uppdaterat: 2024-07-02