Vial

INDIVIDUAL TEST 761

PCA 2 (Purkinje cell antibodies)

Indication Suspicion of paraneoplastic syndrome. 

Method Indirect immunofluorescence. 

Result The result is reported as negative or positive with titer. 

Interpretation The antigen PCA-2 (Purkinje cell antigen 2) is found in Purkinje cells, most major neurons and several tumour types, e.g. breast, ovary and SCLC. The symptoms are encephalomyelitis or cerebellar degeneration. 

Antibodies against PCA-2 are graded as High-risk antibodies with a frequency of 80% of underlying cancer and a positive result yield 3 points PNS score, according to Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. 

References
  • Dalmau J, Geis C, Graus F. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. Physiol Rev. 2017 Apr;97(2):839-887. PMID: 28298428 
  • Alexopoulos H, Dalakas MC. The immunobiology of autoimmune encephalitides. J Autoimmun. 2019 Nov;104:102339. PMID: 31611142. 
  • Graus F, et al. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. Neurol Neuroimmunol Neuroinflamm. 2021 May 18;8(4):e1014. PMID: 34006622

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Vial

ENSKILD ANALYS 761

PCA-2 (Purkinjecells-antikroppar)

Indikation Misstanke om paraneoplastiskt syndrom. 

Metod Indirekt immunoflourescence. 

Svar Resultatet anges som negativt eller positivt med titer. 

Tolkning Antigenet PCA-2 finns i purkinjeceller (purkinjecellsantigen 2), de flesta större neuroner och flera tumörtyper som bröst, ovarie, SCLC, thymom samt vid Hodgkins lymfom. Symptomen är encephalomyelit eller cerebellär degeneration. 

Antikropparna riktade mot PCA-2  bedöms vara High-risk antibodies med en förekomst på 80% för en underliggande cancer och positivitet ger 3 poäng i PNS score enligt Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. 

Referenser
  • Dalmau J, Geis C, Graus F. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. Physiol Rev. 2017 Apr;97(2):839-887. PMID: 28298428 
  • Alexopoulos H, Dalakas MC. The immunobiology of autoimmune encephalitides. J Autoimmun. 2019 Nov;104:102339. PMID: 31611142. 
  • Graus F, et al. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. Neurol Neuroimmunol Neuroinflamm. 2021 May 18;8(4):e1014. PMID: 34006622

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