INDIVIDUAL TEST 761
PCA 2 (Purkinje cell antibodies)
IndicationSuspicion of paraneoplastic syndrome.MethodIndirect immunofluorescence.AnswerThe result is given as negative or positive with titer.InterpretationThe antigen PCA-2 (Purkinje cell antigen 2) is found in Purkinje cells, most major neurons and several tumour types, e.g. breast, ovary and SCLC. They often present as encephalomyelitis or cerebellar degeneration.
ENSKILD ANALYS 761
PCA-2 (Purkinjecells-antikroppar)
Indikation
Misstanke om paraneoplastiskt syndrom.
Metod
Indirekt immunofl ourescence.
Svar
Resultatet anges som negativt eller positivt med titer.
Tolkning
Antigenet PCA-2 finns i purkinjeceller (purkinjecellsantigen 2), de flesta större neuroner och flera tumörtyper som bröst, ovarie, SCLC, thymom samt vid Hodgkins lymfom. Presenterar sig ofta som encephalomyelit eller cerebellär degeneration.