DIAGNOSTIC TEST PANEL 539
Small Fiber Neuropathy (SFN) – Extended Analysis
Diagnostic test panel for antibodies against SSA, SSB, TG2, CASPR2, CV2/CRMP5, and PCA 2. For Suspicion of Small Fiber Neuropathy (SFN).
Indication
Suspicion of Small Fiber Neuropathy (SFN)
Clinical background
Small fiber neuropathy (SFN) is a heterogeneous group of disorders affecting unmyelinated nerve fibers. Typical symptoms of SFN include neuropathic pain and autonomic disturbances.
The underlying cause is often unclear, but diabetes, sarcoidosis, hepatitis C, autoimmunity, Sjögrens syndrome, vitamin deficiency, toxic exposures, amyloidosis, paraneoplastic syndromes, and some rare genetic disorders have been reported. SFN can overlap with other muscle/pain syndromes and be found in fibromyalgia, be associated with muscle cramps and complex regional pain syndrome. SFN has been reported in up to 40% of patients with fibromyalgia.
In this autoantibody screening test the following specificities are included:
- SSA/Ro60 antibodies are markers for Sjogren’s syndrome and systemic lupus erythematosus but can also be seen in other rheumatic systemic diseases.
- SSB (La) antibodies occur almost always in conjunction with anti-SSA and are frequently found in primary Sjogren’s syndrome and systemic lupus erythematosus.
- Transglutaminase IgA (TG2) is a strong diagnostic marker for celiac disease. SFN and sensory disturbances can precede the diagnosis of celiac disease.
- CV2/CRMP5 antibodies are paraneoplastic markers primarily associated with small cell lung cancer but may also be associated with other types of tumors. Clinical symptoms may be chorea, sensorimotor neuropathy, limbic encephalitis, and cerebellar degeneration.
- PCA2 antibodies, the Purkinje cell antigen 2 antibodies are primarily associated with cancer in breast, ovary, and lung (SCLC). Encephalomyelitis, ataxia and cerebellar degeneration are typical. SFN has also been reported but seems to be rare.
- CASPR2 antibodies, Contactin Associated Protein 2 (CASPR2) is an extracellular antigen and a subunit of the potassium channel complex (VGKC). Antibodies against CASPR2 have been reported in patients with SFN, neuromyotonia, autoimmune encephalitis, and Morvan Syndrome.
Reference
- Zeidman LA. Advances in the Management of Small Fiber Neuropathy. Neurol Clin. 2021 Feb;39(1):113-131. doi: 10.1016/j.ncl.2020.09.006. Epub 2020 Nov 7. PMID: 33223078
Tests included in panel
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How to order
This test panel is available worldwide for hospitals, clinics, and physicians.
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Print and complete the request form
Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. -
Prepare your samples
Serum: At least 3 mL serum (plain serum tubes without additives).
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Send samples and request form
Within Sweden
Samples can be sent at room temperature to:
Envelopes and smaller boxes:
Wieslab AB, Box 50117, 20211 Malmö, Sweden
Larger boxes and frozen samples:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
International
Send samples cold to:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
Last updated: 2025-08-18
