INDIVIDUAL TEST 804

Antibodies against TS-HDS (Trisulfated heparin disaccharide)

IndicationSmall fiber neuropathy
MethodThe analysis was performed with EIA. The method is not yet validated for clinical laboratory routine.
AnswerResults are reported as negative or positive with a titer.
InterpretationIgM-antibodies against TS-HDS are reported in a subgroup of patients with small fiber neuropathy (SFN) with unknown underlying cause. These antibodies activate complement and immune therapy may be effective, clinical trials are ongoing. TS-HDS IgM seems to be more frequent and specific for SFN than IgG-antibodies against fibroblast growth factor receptor 3 (FGFR3).
References1. Farhad K. Current Diagnosis and Treatment of Painful Small Fiber Neuropathy. Curr Neurol Neurosci Rep. 2019 Nov 26;19(12):103. PMID: 31773305.
2. Levine TD, et al. Muscle Nerve. 2020 Apr;61(4):512-515. doi: 10.1002/mus.26748. Epub 2019 Nov 6. PMID: 31650561.
3. Zeidman LA. Advances in the Management of Small Fiber Neuropathy. Neurol Clin. 2021 Feb;39(1):113-131. PMID: 33223078.

More information

Learn more about sampling.
> Read more

Download request forms

Neurology

Can't find what you're looking for? We are here to help

ENSKILD ANALYS 804

Antikroppar mot TS-HDS (Trisulfated heparin disaccharide)

IndikationFintrådsneuropati
MetodAnalysen har utförts med EIA. Metoden är ännu inte validerad för laboratoriediagnostik i klinisk rutin.
SvarSvaret anges som negativt eller positivt med värde
TolkningIgM-antikroppar mot TS-HDS har rapporterats förekomma hos en undergrupp av patienter med fintrådsneuropati utan annan känd underliggande orsak. Antikropparna är komplementaktiverande och immunmodulerande behandling kan ha positiv effekt, kliniska studier pågår. TS-HDS IgM förefaller vara vanligare och mer specifika för fintrådsneuropati än IgG-antikroppar mot fibroblast growth factor receptor 3 (FGFR3).
Referenser1. Farhad K. Current Diagnosis and Treatment of Painful Small Fiber Neuropathy. Curr Neurol Neurosci Rep. 2019 Nov 26;19(12):103. PMID: 31773305.
2. Levine TD, et al. Muscle Nerve. 2020 Apr;61(4):512-515. doi: 10.1002/mus.26748. Epub 2019 Nov 6. PMID: 31650561.
3. Zeidman LA. Advances in the Management of Small Fiber Neuropathy. Neurol Clin. 2021 Feb;39(1):113-131. PMID: 33223078.


Mer information

Mer information om provtagning.
> Läs mer

Ladda ner remiss

Neurologi

Hittar du inte vad du söker? Vi kan hjälpa till