Vial

INDIVIDUAL TEST 804

Antibodies against TS-HDS (Trisulfated heparin disaccharide)

Indication

Small fiber neuropathy

Method

The analysis was performed with EIA. The method is not yet validated for clinical laboratory routine.

Answer

Results are reported as negative or positive with a value.

Interpretation

IgM-antibodies against TS-HDS are reported in a subgroup of patients with small fiber neuropathy (SFN) with unknown underlying cause. These antibodies activate complement and immune therapy may be effective, clinical trials are ongoing. TS-HDS IgM seems to be more frequent and specific for SFN than IgG-antibodies against fibroblast growth factor receptor 3 (FGFR3).

References

1. Farhad K. Current Diagnosis and Treatment of Painful Small Fiber Neuropathy. Curr Neurol Neurosci Rep. 2019 Nov 26;19(12):103. PMID: 31773305.
2. Levine TD, et al. Muscle Nerve. 2020 Apr;61(4):512-515. doi: 10.1002/mus.26748. Epub 2019 Nov 6. PMID: 31650561.
3. Zeidman LA. Advances in the Management of Small Fiber Neuropathy. Neurol Clin. 2021 Feb;39(1):113-131. PMID: 33223078.

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Vial

ENSKILD ANALYS 804

Antikroppar mot TS-HDS (Trisulfated heparin disaccharide)

Indikation

Fintrådsneuropati

Metod

Analysen har utförts med EIA. Metoden är ännu inte validerad för laboratoriediagnostik i klinisk rutin.

Svar

Svaret anges som negativt eller positivt med värde

Tolkning

IgM-antikroppar mot TS-HDS har rapporterats förekomma hos en undergrupp av patienter med fintrådsneuropati utan annan känd underliggande orsak. Antikropparna är komplementaktiverande och immunmodulerande behandling kan ha positiv effekt, kliniska studier pågår. TS-HDS IgM förefaller vara vanligare och mer specifika för fintrådsneuropati än IgG-antikroppar mot fibroblast growth factor receptor 3 (FGFR3).

Referenser

1. Farhad K. Current Diagnosis and Treatment of Painful Small Fiber Neuropathy. Curr Neurol Neurosci Rep. 2019 Nov 26;19(12):103. PMID: 31773305.
2. Levine TD, et al. Muscle Nerve. 2020 Apr;61(4):512-515. doi: 10.1002/mus.26748. Epub 2019 Nov 6. PMID: 31650561.
3. Zeidman LA. Advances in the Management of Small Fiber Neuropathy. Neurol Clin. 2021 Feb;39(1):113-131. PMID: 33223078.


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