Vial

INDIVIDUAL TEST 926

C1 inhibitor function

Indication

Investigation of angioedema 

Method

ELISA 

Response

The result is reported as normal or reduced 

Adult reference range is > 74% of normal serum. 

Interpretation

Results below the reference range limit may indicate hereditary angioedema type 1 (HAE type 1) due to C1-inhibitor deficiency, defect protein (HAE type 2) or consumption of C1-inhibitor (can be seen in some malignancies). The result should primarily be verified with a new sample as well as to include analysis of concentration of C1-inhibitor and C4.   

References

Li, H.H., Zuraw, B., Longhurst, H.J. et al. Subcutaneous C1 inhibitor for prevention of attacks of hereditary angioedema: additional outcomes and subgroup analysis of a placebo-controlled randomized study. Allergy Asthma Clin Immunol 15, 49 (2019). PMID: 31485239 

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Vial

ENSKILD ANALYS 926

C1 inhibitor funktion

Indikation

Vid utredning av angioödem 

Metod

ELISA 

Svar

Resultatet anges som normalt eller sänkt. 

Referensintervall för vuxna är >74% av normalserum. 

Tolkning

Resultat under referensområdesgränsen kan tyda på hereditärt angioödem typ 1 (HAE typ 1) pga C1-inhibitorbrist, defekt protein (HAE typ 2) eller konsumtion av C1-inhibitor (kan ses vid vissa maligniteter). Resultatet bör i första hand verifieras med nytt prov för verifiering och även inkludera analys av koncentration av C1-inhibitor och C4.  

Referenser

Li, H.H., Zuraw, B., Longhurst, H.J. et al. Subcutaneous C1 inhibitor for prevention of attacks of hereditary angioedema: additional outcomes and subgroup analysis of a placebo-controlled randomized study. Allergy Asthma Clin Immunol 15, 49 (2019). PMID: 31485239 

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