INDIVIDUAL TEST 926
C1 INH Function
Indication
Suspicion of angioedema
Sample material
EDTA-plasma
- Minim. volume: 0,5 mL
Transport
- Within Sweden: frozen
- International: frozen
Method
Spectrophotometry
Reference interval
72-129%
Result
The result is reported as normal or low as a percentage of normal human serum.
Interpretation
Results below the lower reference limit may indicate hereditary angioedema (HAE) type 1 or consumption of C1-inhibitor (can be seen in some malignancies). The result should primarily be verified with a new sample as well as to include analysis of the concentrations of C1-inhibitor and C4.
References
- Li HH et al. Allergy Asthma Clin Immunol. 2019. Subcutaneous C1 inhibitor for prevention of attacks of hereditary angioedema: additional outcomes and subgroup analysis of a placebo-controlled randomized study. PMID: 31485239
- Maurer M et al. World Allergy Organ J. 2022. The international WAO/EAACI guideline for the management of hereditary angioedema - The 2021 revision and update. PMID: 35497649
Last updated: 2025-12-05
Can't find what you're looking for? We are here to help
ENSKILD ANALYS 926
C1-INH funktion
Indikation
Misstanke om angioödem
Provmaterial
EDTA-plasma
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: fryst
- Internationellt: fryst
Metod
Spektrofotometri
Referensintervall
72-129%
Resultat
Resultatet anges som normal eller sänkt med procent av normalt humanserum.
Tolkning
Resultat under nedre referensgränsen kan tyda på hereditärt angioödem (HAE) typ 1 eller konsumtion av C1-inhibitor (kan ses vid vissa maligniteter). Resultatet bör i första hand verifieras med nytt prov för verifiering och även inkludera analys av koncentration av C1-inhibitor och C4.
Referenser
- Li HH et al. Allergy Asthma Clin Immunol. 2019. Subcutaneous C1 inhibitor for prevention of attacks of hereditary angioedema: additional outcomes and subgroup analysis of a placebo-controlled randomized study. PMID: 31485239
- Maurer M et al. World Allergy Organ J. 2022. The international WAO/EAACI guideline for the management of hereditary angioedema - The 2021 revision and update. PMID: 35497649
Senast uppdaterat: 2025-12-05