NEW SPECIALIST REVIEW: Complement System

We are pleased to introduce a new edition of Svar’s Complement System Specialist Review, an invaluable resource designed to enhance the understanding of the complement system’s role in health and disease, and its potential use in diagnostics and treatment development.

Building upon and expanding previous editions, the authors — Prof. Tom Eirik Mollnes, Prof. Peter Garred, and Prof. Reinhard Würzner — offer a comprehensive overview of the complement system’s physiological functions and its numerous pathological implications, while also examining current research trends, the complement therapeutics landscape, and best practices in complement testing.

Growing evidence demonstrates the involvement of the complement system in a wide range of diseases and pathological processes, driving a mounting interest in the development of complement‑targeted therapeutics. This Specialist Review provides an up-to-date review of some conditions in which complement dysregulation is most clearly defined, and also highlights the expanding therapeutic potential of complement modulation across multiple disease areas, including the proposed role of complement modulation in cancer therapy.