A Novel Method for ADCC Activity Quantification using Engineered Effector Cells

Scientific poster title: "A novel method for quantification of ADCC activity based on the use of engineered effector cells and a series of matching target cells"

In this scientific poster, we showcase how a method for quantification of ADCC activity based on the use of novel engineered effector cells carrying a reporter gene. In addition, novel target cells have been developed that express a constant high level of the specific antigen as well as the homologous control target cells which allows differences in ADCC activity to be determined with precision and a high degree of specificity.

The iLite® technology can be adapted for many applications throughout the drug development phases including drug manufacturing processes such as the quantification of vector potency and functionality or the detection of neutralizing anti-drug antibodies (NAb).