Systematic Analysis of Fc Mutations Designed to Modulate Functional Activity
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Systematic Analysis of Fc Mutations Designed to Modulate Functional Activity

 

Understanding how Fc engineering influences antibody function is essential for optimizing therapeutic efficacy while maintaining patient safety. 

In this collaborative study with mAbsolve, a large panel of commonly used Fc-engineered antibody variants - designed to either suppress or enhance Fc activity - was systematically evaluated for Fc receptor binding, effector function, and thermal stability. 

Download the poster to discover how Svar’s iLite® assays provide a robust and sensitive platform for assessing ADCC, ADCP, and CDC activity, enabling detailed and multifaceted evaluation of the functional impact of Fc engineering on Fc effector activity. 

Fill in the form to download the poster