DIAGNOSTIC TEST 086

Adrenal Cortex Antibodies

Diagnostic test for antibodies against the adrenal cortex. For suspicion of primary Addison’s disease (idiopathic adrenal cortex insufficiency).

Indication

Suspicion of primary Addison’s disease (idiopathic adrenal cortex insufficiency)

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

Indirect immunofluorescence (IIF)

Reference interval

<1:20 negative

Result

Results are reported as negative or positive with fluorescence intensity.

Interpretation

Antibodies against adrenal cortex are detected in about 70% of patients with primary adrenal cortex insufficiency which is more common in women and associated with other autoimmune diseases, e.g. Hashimoto’s thyroiditis, juvenile diabetes mellitus or pernicious anemia. Analysis of autoantibodies against 21-hydroxylas is to be preferred since they are a more sensitive and more specific marker for this disease.

References

  • Nikoshkov A et al. J Immunol. 1999. A conformation-dependent epitope in Addison's disease and other endocrinological autoimmune diseases maps to a carboxyl-terminal functional domain of human steroid 21-hydroxylase. PMID: 9973524
  • Falorni A et al. Fertil Steril. 2002. Steroid-cell autoantibodies are preferentially expressed in women with premature ovarian failure who have adrenal autoimmunity. PMID: 12137862
  • Saverino S, Falorni A. Best Pract Res Clin Endocrinol Metab. 2020 Autoimmune Addison's disease. PMID: 32063488

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-10-09