DIAGNOSTIC TEST PANEL 540

Autoimmune nodopathy/CIDP – subclass screen (IgG1-4)

Diagnostic test panel for antibodies against NF155 (IgG1-4), NF186 (IgG1-4), and CNTN1/CASPR1 (IgG1-4). For suspicion of Inflammatory Neuropathy or Autoimmune Nodopathy.

Indication

Suspicion of inflammatory Neuropathy/Autoimmune Nodopathy

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

Within Sweden

  • room temperature

International

  • cold

Clinical background

Autoimmune nodopathies have until recently been regarded as subgroups of CIDP, but are distinct in both disease course and treatment and are now regarded as separate disorders.

IgG1 and/or IgG3 subclass antibodies are complement activating, which is associated with a more aggressive disease course.

The panel includes a comprehensive analysis of all subclasses IgG1, IgG2, IgG3, and IgG4 with a live cell-based assay (CBA) for the following antibodies:

  • Neurofascin-155 and Neurofascin-186 antibodies (IgG). Neurofascin-155 (NF155) is a paranodal protein while Neurofascin-186 (NF186) is a protein present in the nodes of Ranvier. IgG antibodies against NF155 and NF186 have been reported in autoimmune nodopathy. The simultaneous presence of antibodies against NF155 and NF186 is seen in pan-neurofascin nodopathy.
  • Contactin-1/ CASPR1 antibodies (IgG). Contactin-1 (CNTN1) and Contactin-associated protein 1 (CASPR1) are paranodal proteins. IgG antibodies against CNTN1 and CASPR1 have been reported in autoimmune nodopathy.

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How to order

This test panel is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-08-18