DIAGNOSTIC TEST 536

BPI-ANCA (IgG, IgA)  

Diagnostic test for BPI-ANCA (IgG, IgA). For the assessment of the prognosis of cystic fibrosis.

Indication

Suspicion of cystic fibrosis, control of disease activity or assessment of prognosis

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

ELISA

Reference interval

BPI IgA: <53 units negative, 53-67 borderline

BPI IgG: <38 units negative, 38-50 borderline

Result

Results are reported as negative, borderline or positive with a value.

Interpretation

Antibodies against Bactericidal/permeability-increasing protein

(BPI)-ANCA are present in various inflammatory states but have only clinical significance in cystic fibrosis. In case of cystic fibrosis, the presence of BPI-ANCA indicates infection with pseudomonas, and high levels are associated with poor lung

function.

References

  • Sedivá A et al. Microbes Infect. 2003. Antineutrophil cytoplasmic antibodies directed against bactericidal/permeability-increasing protein detected in children with cystic fibrosis inhibit neutrophil-mediated killing of Pseudomonas aeruginosa. PMID: 12593970
  • Carlsson M et al. Clin Exp Rheumatol. 2003. Pseudomonas-induced lung damage in cystic fibrosis correlates to bactericidal-permeability increasing protein (BPI)-autoantibodies. PMID: 14740434
  • Lindberg U et al. J Immunol Res. 2015. BPI-ANCA Provides Additional Clinical Information to Anti-Pseudomonas Serology: Results from a Cohort of 117 Swedish Cystic Fibrosis Patients. PMID: 26273683
  • Theprungsirikul J et al. J Transl Autoimmun. 2021 Killing three birds with one BPI: Bactericidal, opsonic, and anti-inflammatory functions. PMID: 34142075.
  • Iwuji K et al. Sci Rep. 2023 Clinical significance of BPI-ANCA in patients with cystic fibrosis: a single center prospective study. PMID: 37875496

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-12-05