DIAGNOSTIC TEST 100

GBM Antibodies (IgG4)

Diagnostic test for antibodies against GBM (IgG4). For suspicion of Goodpasture’s syndrome, GPA, and other reno-pulmonary syndromes.

urgent

Available as urgent test with results within 48 h.

Indication

Follow-up analysis of Goodpasture’s syndrome, GPA, and other reno-pulmonary syndromes. It may indicate patients who should be monitored very closely and may predict relapses.

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

ELISA

Reference interval

<7 U/mL negative

Result

Results are reported as negative or positive with concentration.

Interpretation

Antibodies against GBM are usually dominated by IgG1, but all subclasses can be present. Isolated presence of antibodies of IgG4 subclass have been reported in cases with severe lung disease with or without mild kidney damage.

References

  • Segelmark M et al. Nephrol Dial Transplant. 1990. Antigen restriction and IgG subclasses among anti-GBM autoantibodies. PMID: 2128958
  • Segelmark M, Wieslander J. Nephrol Dial Transplant. 1993. IgG subclasses of antineutrophil cytoplasm autoantibodies (ANCA). PMID: 8414154
  • Boomsma MM et al. Arthritis Rheum. 2000. Prediction of relapses in Wegener's granulomatosis by measurement of antineutrophil cytoplasmic antibody levels: a prospective study. PMID: 11014352
  • Bharati J et al. Kidney Int Rep. 2023. Atypical Anti-Glomerular Basement Membrane Disease. PMID: 37284681
  • Ohlsson S et al. Am J Kidney Dis. 2014. Circulating anti-glomerular basement membrane antibodies with predominance of subclass IgG4 and false-negative immunoassay test results in anti-glomerular basement membrane disease. PMID: 24189476

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-10-09