DIAGNOSTIC TEST 996

GFAp Antibodies (IgG)

Diagnostic test for antibodies against GFAp. For suspicion of autoimmune CNS diseases.

Indication

Suspicion of autoimmune CNS-diseases

Sample material

Serum

  • Minim. volume: 0,5 mL

CSF

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

Indirect immunofluorescence (IIF)

Reference interval

Serum: <1:100 negative

CSF: negative

Result

Results are reported as negative or positive. A positive result is followed by a titer (serum).

Interpretation

Autoantibodies against GFAp have been reported in autoimmune meningo-encephalo-myelitis. Epileptic seizures, meningismus, headache, cognitive impairment, and myelopathy are the most common. Optic neuritis and area postrema syndrome have also been reported.

Antibodies against GFAp are graded as Lower-risk, with an approximate underlying cancer frequency of 20%. According to the “Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes” (see ref. below), positive results have a 0-point PNS score.

References

  • Kunchok A et al. Curr Opin Neurol. 2019. Autoimmune glial fibrillary acidic protein astrocytopathy. PMID: 30724768
  • Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
  • Chukwuocha I et al. Clin Neurol Neurosurg. 2025. Autoimmune glial fibrillary acidic protein astrocytopathy - The benefit of early diagnosis and initiation of therapy: A case report. PMID: 40669121
  • Gravier-Dumonceau A et al. Neurology. 2022. Glial Fibrillary Acidic Protein Autoimmunity: A French Cohort Study. PMID: 34799461

Included in these panels

Need pricing information?

Get a quote

How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).
    CSF: At least 0.5 mL CSF (polypropylene tubes).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-12-02