DIAGNOSTIC TEST 985

Glial Fibrillary Acidic Protein (GFAP)

Diagnostic test for GFAP. For suspicion of CNS damage

Indication

Suspicion of CNS damage

Sample material

Serum

  • Minim. volume: 0,5 mL

CSF

  • Minim. volume: 0,5 mL

Transport

Serum

  • Within Sweden: frozen
  • International: frozen

CSF

  • Within Sweden: frozen
  • International: frozen

Method

Single Molecule Array (SIMOA)

Reference interval

SERUM

Age group Reference interval
18-60 years 20-180 ng/L (median 70), based on sera from 92 healthy individuals
>60 years 40-260 ng/L (median 100), based on sera from 30 healthy individuals

CSF

Age group Reference interval
18-60 years 3900-17700 ng/L (median 8200), based on CSF from 36 individuals without GFAp-related disorders
>60 years 6100-34600 ng/L (median 17800), based on CSF from 16 individuals without GFAp-related disorders

Result

Results are reported as a concentration in ng/L.

Interpretation

Glial fibrillary acidic protein (GFAP) is found in astrocytes and, in the event of damage, can leak into the cerebrospinal fluid (CSF) and cross the blood-brain barrier (BBB) into the blood. The level in blood can be used to monitor astrocyte damage in the central nervous system (CNS). Serum GFAP levels have been shown to be of value in traumatic brain injury (TBI) such as stroke, certain neurodegenerative and neuroinflammatory conditions.

References

  • Abdelhak A et al. Nat Rev Neurol. 2022. Blood GFAP as an emerging biomarker in brain and spinal cord disorders. PMID: 35115728
  • Kim H et al. Front Neurol. 2022. Glial Fibrillary Acidic Protein in Blood as a Disease Biomarker of Neuromyelitis Optica Spectrum Disorders. PMID: 35370870
  • Abdelhak A et al. Sci Rep. 2018. Serum GFAP as a biomarker for disease severity in multiple sclerosis. PMID: 30287870

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. If you are a new customer, please also include a completed customer information form.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).
    CSF: At least 0.5 mL CSF (polypropylene tubes).

  3. Send samples and request form

    Within Sweden
    Send samples frozen to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples frozen to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Last updated: 2026-09-21