DIAGNOSTIC TEST 111
IA-2 Antibodies
Diagnostic test for antibodies against IA-2. For suspicion of risk of developing type 1 diabetes (T1D).
Indication
Suspicion of type 1 diabetes (T1D)
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
ELISA
Reference interval
< 10 IU/mL
Result
Results are reported as negative or positive with a concentration.
Interpretation
IgG-antibodies against IA-2 is a marker for type 1 diabetes (T1D) and occurs in 60-70% of patients. Usually other autoantibodies associated with T1D can be found simultaneously. Elevated levels, without manifested T1D, may occur in other autoimmune endocrine diseases, in particular autoimmune thyroiditis.
References
- Hill TG, Hill DJ. Int J Mol Sci. 2024 The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes. PMID: 38612880
- Joglekar MV et al. Lancet Diabetes Endocrinol. 2024. Prediction of progression to type 1 diabetes with dynamic biomarkers and risk scores. PMID: 38797187
- Phillip M et al. Diabetes Care. 2024. Consensus Guidance for Monitoring Individuals With Islet Autoantibody-Positive Pre-Stage 3 Type 1 Diabetes. PMID: 38912694
Included in these panels
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How to order
This test is available worldwide for hospitals, clinics, and physicians.
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Print and complete the request form
Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. -
Prepare your samples
Serum: At least 0.5 mL serum (plain serum tubes without additives).
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Send samples and request form
Within Sweden
Samples can be sent at room temperature to:
Envelopes and smaller boxes:
Wieslab AB, Box 50117, 20211 Malmö, Sweden
Larger boxes and frozen samples:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
International
Send samples cold to:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
Last updated: 2025-12-08
